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diagnosis differential hematology management disease oncology signs spinal spinalcord syndromes vitaminb12 agglutinin algorithm alkaline alp aplastic b1 behcet cobalamin cold
Clinically Important Vitamins and Vitamin Deficiency States Fat-soluble Vitamins: • Vitamin A - Xerophthalmia, night blindness,
Clinically Important ... Vitamins and Vitamin Deficiency ... Wernicke-Korsakoff syndrome ... diagnosis #signs #symptoms ... #nutrition
Wernicke Encephalopathy - Acute B1 (Thiamine) Deficiency - Diagnosis and Management Diagnosis - Caine Criteria (2 of
treatment can improve symptoms ... development of Korsakoff syndrome ... (chronic B1 deficiency ... Diagnosis #Management #neurology ... #nutrition
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
Diseases: • GATA2 deficiency ... • Fanconi’s anemia ... Wiskott-Aldrich syndrome ... Antibody-mediated hemolysis Nutritional ... consumption • Vitamin B12
Lesions of the Spinal cord - Spinal Cord Syndromes Spinal cord lesions can result in permanent neurologic
- Spinal Cord Syndromes ... result in permanent neurologic ... HIV) - Vitamin B12 ... , Copper deficiency ... Lower motor neuron symptoms
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Clinical Presentation ... , GATA2 deficiency ... , CTLA4 deficiency ... • Improve the symptoms ... #oncology #hematology
Vitamin B12 (Cobalamin) Deficiency Etiology: • Vit B12 - aka cobalamin. Present in foods derived from animal
) Deficiency Etiology ... intrinsic factor, IF) Clinical ... to manifest its symptoms ... , alcohol use, symptoms ... diagnosis #management #nutrition
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Agglutinin Syndrome ... Viral Infection Clinical ... of anemia include ... • hemolytic anemia ... #hematology #diagnosis
The Inhibited Pathway caused by N2O, leading to a decrease in the active form of Vitamin
N2O can cause a syndrome ... of the spinal cord ... deficiency. ... The classic clinical ... of pernicious anemia
Spinal Cord Disorders - Differential Diagnosis Framework Spinal cord neurological lesion: Clinical findings: • Symptoms and signs below
neurological lesion: Clinical ... findings: • Symptoms ... myelopathy - Vit B12 ... MCTD, Sjogren syndrome ... disorders #diagnosis #neurology
Etiologies of Vitamin B12 Deficiency • Inadequate intake - Rare but seen in very strict vegans
autoantibodies (pernicious anemia ... insufficiency, blind loops syndromes ... malabsorption syndromes ... differential #diagnosis #hematology ... #nutrition
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