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diagnosis differential hematology causes management oncology acidosis algorithm alp aplastic classification cobalamin elevatedmcv elevation hepatology hyophosphatasia lactate lactic macrocytosis mcv
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
• Drugs Oval Macrocytes ... • Dietary Deficiency ... - Low Serum B12 ... Myelodysplastic Syndromes ... and Folate Deficiency
Diagnostic Framework for Anemia (Morphological Approach - MCV) Low MCV - <80fL - "Microcytic" • Iron deficiency
Approach - MCV) Low ... " • Iron deficiency ... MCV - >96fL - "Macrocytic ... Megaloblastic: Vitamin B12 ... Myelodysplastic syndrome
Clinically Important Vitamins and Vitamin Deficiency States Fat-soluble Vitamins: • Vitamin A - Xerophthalmia, night blindness,
Clinically Important ... Vitamins and Vitamin Deficiency ... Wernicke-Korsakoff syndrome ... #Vitamins #Deficiency ... signs #symptoms #nutrition
Low Alkaline Phosphatase - Hypophosphatasia Is Low Alkaline Phosphatase Of Clinical Importance? ALP enzyme- Discovered in 1923 Low
Low Alkaline Phosphatase ... Of Clinical Importance ... • Pernicious anemia ... /B12 deficiency ... respiratory failure • Neurologic
Vitamin B12 (Cobalamin) Deficiency Etiology: • Vit B12 - aka cobalamin. Present in foods derived from animal
) Deficiency Etiology ... intrinsic factor, IF) Clinical ... : • Worsening macrocytic ... #Cobalamin #Deficiency ... diagnosis #management #nutrition
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... common cytopenia: Macrocytic ... Platelet Disorders • Nutritional ... : vitamin B12 or ... Workup: • Complete
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Clinical Presentation ... , GATA2 deficiency ... , CTLA4 deficiency ... - Parvovirus B19 ... may result from low
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
malignancy, or thiamine deficiency ... LV failure - Low ... - Compartment syndrome ... 30mmHg) - Severe anemia ... effect - Thiamine deficiency
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