11 results
diagnosis differential algorithm causes management oncology alkaline alp aplastic autoinflammatory cobalamin e1 elevatedmcv hepatology hyophosphatasia low macrocytosis mcv mds morphologic
Approach to Hypoproliferative Macrocytic Anemia • 812, Folate Deficiency • MDS+ • Hypothyroid • Liver Disease
Hypoproliferative Macrocytic ... Anemia • 812 ... , Folate Deficiency ... diagnosis #algorithm #hematology ... #workup
Diagnostic Framework for Anemia (Morphological Approach - MCV) Low MCV - <80fL - "Microcytic" • Iron deficiency
" • Iron deficiency ... MCV - >96fL - "Macrocytic ... Megaloblastic: Vitamin B12 ... Myelodysplastic syndrome ... diagnosis #causes #hematology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
• Drugs Oval Macrocytes ... • Dietary Deficiency ... Myelodysplastic Syndromes ... and Folate Deficiency ... Algorithm #Causes #Hematology
Clinically Important Vitamins and Vitamin Deficiency States Fat-soluble Vitamins: • Vitamin A - Xerophthalmia, night blindness,
Clinically Important ... Vitamins and Vitamin Deficiency ... Wernicke-Korsakoff syndrome ... gestation • Vitamin B12 ... signs #symptoms #nutrition
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
• Fanconi’s anemia ... Wiskott-Aldrich syndrome ... Antibody-mediated hemolysis Nutritional ... consumption • Vitamin B12 ... Differential #Diagnosis #Hematology
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome Clinical Syndrome: • Common Clinical Features: alveolitis, ear and
Clinical Syndrome ... : • Common Clinical ... Abnormalities: macrocytic ... anemia, thrombocytopenia ... polyarteritis nodosa (12%
Vitamin B12 (Cobalamin) Deficiency Etiology: • Vit B12 - aka cobalamin. Present in foods derived from animal
) Deficiency Etiology ... intrinsic factor, IF) Clinical ... : • Worsening macrocytic ... #Cobalamin #Deficiency ... diagnosis #management #nutrition
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Clinical Presentation ... , GATA2 deficiency ... , CTLA4 deficiency ... - Parvovirus B19 ... #oncology #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... common cytopenia: Macrocytic ... Platelet Disorders • Nutritional ... : vitamin B12 or ... #diagnosis #hematology
Etiologies of Vitamin B12 Deficiency • Inadequate intake - Rare but seen in very strict vegans
autoantibodies (pernicious anemia ... insufficiency, blind loops syndromes ... malabsorption syndromes ... differential #diagnosis #hematology ... #nutrition
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