17 results
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Low Mean Corpuscular Volume (<80
Inflammation, Chronic Infection ... (>100 fL) • B12 ... Deficiency • ... Folate Deficiency ... #MCV #Classification
Vitamin B12 (Cobalamin) Deficiency
Etiology:
 • Vit B12 - aka cobalamin. Present in foods derived from animal
) Deficiency Etiology ... intrinsic factor, IF) Clinical ... to IBD, celiac disease ... to manifest its symptoms ... , alcohol use, symptoms
Fatigue and IBD Algorithm
 • 40-50% patients have fatigue despite clinical remission
 • Risk factors: BMI,
fatigue despite clinical ... Crohn's > UC Anemia ... restricted diet/deficiency ... symptoms even if ... fatigue despite disease
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
Clinical Presentation ... , GATA2 deficiency ... , CTLA4 deficiency ... Idiopathic • Infections ... • Improve the symptoms
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
Diagnosis and Workup ... procedures - Infection ... pylori test (GI symptoms ... (CVID, WAS), (neurologic ... changes), high MCV anemia
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
Malnutrition • Wilson's disease ... • Pernicious anemia ... /B12 deficiency ... mineralization Symptoms ... respiratory failure • Neurologic
Nontuberculous Mycobacteria (NTM) Infections 

Mycobacterial species other than those belonging to the Mycobacterium tuberculosis complex and
Growers (Runyon Classification ... gastrointestinal symptoms ... Bone Marrow - Anemia ... : • Clinical ( ... Symptoms, Imaging
Transverse Myelitis Overview

Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
Transverse Myelitis - Clinical ... Bilateral signs and/or symptoms ... Check Vitamin B12 ... • Nutritional Deficiency ... diagnosis #management #neurology
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... age 70 years Symptoms ... Myeloproliferative Disease ... Nutritional: vitamin B12 ... Workup: • Complete
The Stages of Syphilis 

Primary Syphilis 
- The chancre lesion is the hallmark of primary syphilis.
to asymptomatic infection ... exposure to or symptoms ... similar to those of B12 ... deficiency. ... Diseases - https