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diagnosis management causes cord spinalcord algorithm disorders encephalopathy gitelman gravis lesions myasthenia myelitis neuromuscular pathophysiology posterior pres reversible rhabdomyolysis syndromes
Causes of Neuromuscular Weakness • Spinal Cord: Demyelinating Disease (MS), Epidural abscess, Infarction, Syringomyelia, Tetanus, Transverse
Neuromuscular Weakness ... • Spinal Cord: ... heavy metals), Critical ... #Causes #differential ... #diagnosis #neurology
Lesions of the Spinal cord - Spinal Cord Syndromes Spinal cord lesions can result in permanent neurologic
Syndromes Spinal ... result in permanent neurologic ... HIV) - Vitamin B12 ... #lesions #differential ... #diagnosis #neurology
Spinal Cord Disorders - Differential Diagnosis Framework Spinal cord neurological lesion: Clinical findings: • Symptoms and signs below
- Differential ... neurological lesion: Clinical ... myelopathy - Vit B12 ... MCTD, Sjogren syndrome ... disorders #diagnosis #neurology
Weakness - Differential Diagnosis Framework Approach To Weakness: • Non-neuromuscular disorder (Cardiac, pulmonary etc) • CNS ->
Weakness - Differential ... Lesions of the spinal ... endocrine: Vitamin B12 ... #Differential # ... Diagnosis #neurology
Gitelman Syndrome Overview What? • Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter • Gitelman's syndrome
present in the apical ... tubule (DCT) Clinical ... Fatigue • Muscle weakness ... ratio 0.5%) Differential ... #diagnosis #nephrology
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
Transverse Myelitis - Clinical ... Check Vitamin B12 ... Deficiency: - Vitamin B12 ... diagnosis #management #neurology ... #differential
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary Causes of Rhabdomyolysis: • Trauma: - Immobilization - Crush injury - Compartment
Rhabdomyolysis - Differential ... Dermatomyositis Clinical ... Muscle pain - Weakness ... Rhabdomyolysis #Differential ... causes #treatment #nephrology
Myasthenia Gravis Overview Myasthenia Gravis is an autoimmune disorder of the postsynaptic neuromuscular junction. Ab to
Clinical Picture ... life-threatening Differential ... Clinical DX: - ... immunosuppressants - Meds ... diagnosis #management #neurology
Posterior Reversible Encephalopathy Syndrome (PRES) Overview Clinico-Radiological Syndrome, characterized by: • Headache • Seizures • Altered mental
brain PRES Clinical ... may precede the neurologic ... Reversible course Differential ... Seizures: Treat with AEDs ... diagnosis #management #neurology
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