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management cord spinalcord weakness algorithm causes disease disorders encephalopathy gitelman gravis hp hypertrophic hypokalemia lesions myasthenia myelitis neuromuscular pachymeningitis pathophysiology
Causes of Neuromuscular Weakness • Spinal Cord: Demyelinating Disease (MS), Epidural abscess, Infarction, Syringomyelia, Tetanus, Transverse
Neuromuscular Weakness • Spinal ... heavy metals), Critical ... Shellfish poisoning, Meds ... Weakness #Causes #differential ... #diagnosis #neurology
Spinal Cord Disorders - Differential Diagnosis Framework Spinal cord neurological lesion: Clinical findings: • Symptoms and signs below
neurological lesion: Clinical ... myelopathy - Vit B12 ... - Sarcoidosis, Behcet ... MCTD, Sjogren syndrome ... #neurology #differential
Lesions of the Spinal cord - Spinal Cord Syndromes Spinal cord lesions can result in permanent neurologic
Syndromes Spinal ... result in permanent neurologic ... HIV) - Vitamin B12 ... #lesions #differential ... #diagnosis #neurology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
skin injury) • Neurologic ... white matter, spinal ... syndrome (Clinical ... disease) Differential ... #Syndrome #diagnosis
Weakness - Differential Diagnosis Framework Approach To Weakness: • Non-neuromuscular disorder (Cardiac, pulmonary etc) • CNS ->
Weakness - Differential ... Diagnosis Framework ... Lesions of the spinal ... endocrine: Vitamin B12 ... #Diagnosis #neurology
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
Transverse Myelitis - Clinical ... Check Vitamin B12 ... Deficiency: - Vitamin B12 ... #management #neurology ... #differential
Posterior Reversible Encephalopathy Syndrome (PRES) Overview Clinico-Radiological Syndrome, characterized by: • Headache • Seizures • Altered mental
brain PRES Clinical ... may precede the neurologic ... Reversible course Differential ... Seizures: Treat with AEDs ... #neurology
Hypertrophic Pachymeningitis - Differential Diagnosis Framework Pachymeningitis is a rare condition that causes areas of a layer
Diagnosis Framework ... surrounds the spinal ... polychondritis • Behçet ... brain sagging syndrome ... Pachymeningitis #HP #Neurology
Myasthenia Gravis Overview Myasthenia Gravis is an autoimmune disorder of the postsynaptic neuromuscular junction. Ab to
life-threatening Differential ... myasthenia Diagnosis ... immunosuppressants - Meds ... Myasthenia #Gravis #diagnosis ... #management #neurology
Gitelman Syndrome Overview What? • Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter • Gitelman's syndrome
Gitelman Syndrome ... present in the apical ... tubule (DCT) Clinical ... ratio 0.5%) Differential ... #diagnosis #nephrology
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