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diagnosis algorithm differential pbc primary lfts management syndrome causes chemistry cholangitis hepatitis hepatopulmonary hps injury interpretation liverenzymes rheumatology rvalue sjogrens
Primary Biliary Cirrhosis - Diagnosis Algorithm Symptoms: Fatigue, Pruritus, Right upper quadrant discomfort Signs: Jaundice, Xanthelasmata, Hepatomegaly Associated history:
Primary Biliary ... Cirrhosis - Diagnosis ... Elevated ALP 2. ... Liver biopsy findings ... #Algorithm #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Extrahepatic - Biliary ... Choledocholithiasis, Biliary ... - Obstruction: Biliary ... hepatitis: < 1 • Cirrhosis ... diagnosis #algorithm #hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... • Pregnancy - AFLP ... • Cholestatic disease ... Duct Stone • Biliary ... Others #LFTs #Hepatology
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
/Liver failure ... obstruction • ALP ... or higher • Liver ... cholangitis #diagnosis #workup ... #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
of cholestatic disease ... disease: > 2 ... hepatitis: < 1 • Cirrhosis ... Bilirubin: RBC (hemolysis ... #differential #Hepatology
Primary Biliary Cirrhosis - Management A. Initiate therapy - Initiate 1st line therapy with UDCA (13-15
Primary Biliary ... line therapy if ALP ... bilirubin despite 12 ... Stage & survey disease ... #Treatment #hepatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
vasculitis: 10%-16% Liver ... hepatitis, primary biliary ... cirrhosis: 3%-20% ... Nephrogenic DI Hematologic ... Adenocarcinoma Treatment
Hepatopulmonary Syndrome - Illness Script HPS is a pulmonary disorder of chronic liver disease characterized by a
• Stigmata of cirrhosis ... the left heart TREATMENT ... mortality rate of ~12% ... only definitive treatment ... #diagnosis #hepatology
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