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Antiarrhythmics Pharmacology Summary Cardiac Conduction Phases: Phase 0 - Ventricular Depolarization: • Na+ channels open leading to a
Classification: CLASS ... duration - CLASS ... duration - CLASS ... & AP duration CLASS ... ) CLASS 4 - Calcium
Action potential in cardiomyocytes The action potential in typical cardiomyocytes is composed of 5 phases (0-4), beginning
phase Phase 0: Depolarization ... Phase 1: Early repolarization ... phase Phase 3: Repolarization ... Myocytes #Phases #Depolarization ... #Repolarization
Antiarrhythmics - Vaughan Williams Classification: CLASS 1 - Sodium Channel Blockers: • MOA: Block fast Na+ channels
Classification: CLASS ... and magnitude of depolarization ... prolong AV node repolarization ... interval (delays time repolarization ... prolong AV node repolarization
Class I Antiarrhythmics and their Key Pharmacologic Properties Class IA = Quinidine, Procainamide, Disopyramide ("Quarter PounDer") Class IB
Class I Antiarrhythmics ... Properties Class ... Mayo, Pickle") Class ... involved in phase 3 repolarization ... • Prolongs repolarization
Antiarrhythmics - Vaughan Williams Classification Class I (Ia, Ib, Ic) - Na+ Channel Blockade • Slows depolarization
Classification Class ... Blockade • Slows depolarization ... Widens QRS complex Class ... Blockade • Slows depolarization ... Blockade • Slows depolarization
Action Potential: Depolarization and repolarization of a neuron #ActionPotential #Depolarization #Repolarization #Neuron #Neurology #Pathophysiology
Action Potential: Depolarization ... and repolarization ... ActionPotential #Depolarization ... #Repolarization
ECG characteristics of early repolarization - The ST segment elevations are concave and most pronounced in
characteristics of early repolarization ... elevations are concave ... hallmark of early repolarization ... EKG #ECG #Early #Repolarization
Major electrocardiogram findings induced by left ventricular hypertrophy (LVH) An increase in left ventricular mass augments the
alteration in repolarization ... in left atrial depolarization
Hyperkalemia shortens repolarization; changes in the T wave provide the earliest clues to hyperpotassemia. - At
Hyperkalemia shortens repolarization ... 6.0 mEq/L, rapid repolarization ... causes peaked T ... in conduction causes ... wave to produce classic
Causes of ST Segment Elevation - Differential Diagnosis Framework STEMI: • Upsloping convex STE: "Pardee's sign" +
Causes of ST Segment ... Syndromes • Early Repolarization ... : - Early-repolarization ... ST Secondary Repolarization ... voltage Other Causes
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