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Classification of Jaundice Unconjugated hyperbilirubinemia (predominantly indirect bilirubin) • Increased bilirubin production (eg, hemolytic anemias, hemolytic reactions,
genes coding for bile ... cholestasis, and some cases ... miscellaneous causes ... external pressure on bile ... #differential #causes
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
disease US — Normal Bile ... US - Dilated Bile ... Ducts • Common Bile ... Duct Stone • Biliary ... Diagnosis #Algorithm #Causes
Localized skin infections and associations: Cellulitis, Bite wounds, Ulcers, Nodules, Eschars #SSTIs #associations #SkinInfections #cellulitis #ulcer #eschar #bites #nodules #differential #diagnosis #infectiousdisease
associations: Cellulitis, Bite ... ulcer #eschar #bites
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
Primary Biliary ... of intralobular bile ... ducts causes cholestasis ... No extrahepatic biliary ... malignancy #Primary #Biliary
Mechanism of Action of Bile Acid Sequestrants Bile Acid Sequestrants → ↓ Hepatic Bile Acid Pool →
Mechanism of Action of Bile ... Sequestrants Bile ... Sequestrants → ↓ Hepatic Bile ... Pool → ↑ Hepatic Bile ... Plasma LDL-C #biliary
Causes of Severe Acute Liver Injury - Ichemic hepatitis - Acute biliary obstruction - Drug-Induced liver
Causes of Severe ... hepatitis - Acute biliary ... Hemochromatosis - Primary biliary ... Severe #Acute #Causes
Diseases of the Biliary Tract Asymptomatic gallstones - Asymptomatic Symptomatic gallstones - Biliary pain Cholesterolosis of gallbladder - Usually
Diseases of the Biliary ... Adenomyomatosis - May cause ... biliary pain Porcelain ... quadrant pain, nausea ... quadrant pain, nausea
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm ALP: - Enzymes that catalyze hydrolysis of organic phosphate
Intestine - Other causes ... Drugs - Primary biliary ... PSC - Other biliary ... diseases/Bile duct
Uveitis - Definition, Causes and SUN Classification Inflammation of the iris, ciliary body, vitreous, retina and/or choroid Incidence
- Definition, Causes ... Inflammation of the iris, ciliary ... inhabitants 3rd leading cause ... retinal ischemia Causes ... TerrierBen #Uveitis #Causes
Primary Biliary Cirrhosis - Pathophysiology Environmental Risk Factors: Geographic location, Smoking, Microbial triggers, Xenobiotics, Nail polish Epigentics Risk
Primary Biliary ... gradual loss of bile ... inflammation and biliary ... #PBC #Primary #Biliary
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