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diagnosis hepatology differential cbd clinical management ultrasound bileduct lfts liver pbc primary treatment activetb ascariasis cholangitis cirrhosis dilated disorders gastroenterology
Mechanism of Action of Bile Acid Sequestrants Bile Acid Sequestrants → ↓ Hepatic Bile Acid Pool →
Acid Sequestrants ... Bile Acid Sequestrants ... Bile Acid Synthesis ... Plasma LDL-C #biliary ... #pathophysiology
Primary Biliary Cirrhosis - Pathophysiology Environmental Risk Factors: Geographic location, Smoking, Microbial triggers, Xenobiotics, Nail polish Epigentics Risk
Primary Biliary ... Cirrhosis - Pathophysiology ... gradual loss of bile ... inflammation and biliary ... #PBC #Primary #Biliary
Irritable Bowel Syndrome (IBS) Treatment Algorithm IBS-Constipation: • Constipation: Osmotic laxatives • Abdominal pain: Antispasmodics IBS-Diarrhea: • Diarrhea:
IBS) Treatment Algorithm ... Diarrhea: Loperamide, Bile ... acid sequestrant ... Treatment #Management #Algorithm
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Differential Diagnosis Algorithm ... US - Dilated Bile ... Ducts • Common Bile ... Duct Stone • Biliary ... Differential #Diagnosis #Algorithm
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
Differential Diagnosis Algorithm ... • US - Normal Bile ... • US - Dilated Bile ... - CBD stone, Biliary ... Transaminitis #Algorithm
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
Primary Biliary ... 65 years PBC Pathophysiology ... of intralobular bile ... No extrahepatic biliary ... malignancy #Primary #Biliary
Common Bile Duct Stone on POCUS Here’s a similar case in a 70yo F with a remote
Common Bile Duct ... Stone on POCUS ... This time on pocus ... Choledocholithiasis #POCUS ... clinical #ultrasound #biliary
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 Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm ALP: - Enzymes that catalyze hydrolysis of organic phosphate
Differential Diagnosis Algorithm ... Drugs - Primary biliary ... PSC - Other biliary ... diseases/Bile duct ... Differential #Diagnosis #Algorithm
Lipoprotein Metabolism Enterocytes release absorbed lipids the form of triglyceride-rich chylomicrons. These are acted upon by endothelial
producing fatty acids ... lipoproteins (VLDLs) and bile ... acids. ... tissues with fatty acids ... Cholesterol #Metabolism #Pathophysiology
Liver Chemistry Tests - AST, ALT, Alkaline Phosphatase and Bilirubin Metabolism AST and ALT: • AST: liver
membrane (NOT within bile ... stimulated by bile ... acid accumulation ... bilirubin into bile ... Bilirubin #Hepatology #Pathophysiology
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