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diagnosis rheumatology management activation acute autoimmune classification congenital cryofibrinogenemia cryoglobulinemia cryoglobulins hemolytic hepatology hiv hyperbilirubinemia inherited macrophage mas mds myelodysplasia
Warm Antibody Autoimmune Hemolytic Anemia 1) DIAGNOSE AIHA • Anemia: macrocytic > normocytic, ↑ reticulocytes •
Warm Antibody Autoimmune ... haptoglobin ↑ indirect bilirubin ... Coombs • IgG type ... 2) LOOK FOR a cause ... → Systematic screening
Inherited Non-hemolytic Disorders of Hyperbilirubinemia == Disorders of Conjugation == Gilbert Syndrome: • 5-10% of the population
: • Type I CN ... type II rarely ... and stress may cause ... #hepatology #diagnosis ... #gastroenterology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
activate the immune system ... , leading to the ... • They can cause ... Cryoglobulins Cause ... Antineutrophil cytoplasmic antibody
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
group of disorders caused ... unusual bruising or bleeding ... skin that are caused ... by bleeding (petechiae ... #diagnosis #hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
purpura to mucosal bleeding ... with leukopenia, anemia ... ↑ AST ↑ ALT ↑ bilirubin ... Diagnosis #Management #Hematology ... #Rheumatology
Acute Retroviral Syndrome Acute Retroviral Syndrome is the symptomatic presentation of acute human immunodeficiency virus infection •
mononucleosis/flu type ... Central nervous system ... enzymes ↑ • Mild anemia ... Detects both HIV antibody ... IgM-sensitive HIV-1 antibody
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
Paradoxical spontaneous bleeding ... Divided Into Two Types ... processes: • Systemic ... Antiphospholipid syndrome ... #hematology
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