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diagnosis oncology management differential microscopy smear activation algorithm analysis aplastic atlas blood cancer causes coagulation comparison cryofibrinogenemia disseminated hemolytic hodgkins
Peripheral Blood Smear Analysis Hypochromia Megaloblastic Anemia Schistocytes: Microangiopathic hemolytic anemia (e.g. DIC, TTP, HUS) Microspherocytes: Autoimmune hemolytic anemia Sickled red
DIC, TTP, HUS) ... Sickled red cells ... Bite cells: G6PD ... Smear #Analysis #hematology ... interpretation #clinical
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Red Blood Cell ( ... - Sickle cell anemia ... Liver diseases, Bleeding ... coagulopathy (DIC ... #differential #hematology
Peripheral blood findings in microangiopathic hemolytic anemia. DIC is a clinical and laboratory diagnosis, not
DIC is a clinical ... non-specific red cell ... polychromatophilic cells ... count, D-dimer, egg ... #Hematology #Pathology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
fever, joint pain, bleeding ... night sweats, bleeding ... - infiltrates (anemia ... Fibrinolysis & DIC ... #Leukemia #Hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Intravascular Coagulation (DIC ... Fibrinolysis → End ... organ damage Clinical ... Schistocytes, helmet cells ... treatment #management #hematology
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison Hodgkin's Lymphoma: • Epidemiology: young adults 20-30, older 50-70 •
Autoimmune diseases • Clinical ... Hepatosplenomegaly, cytopenias(bleeding ... Lymphomas • Other hematologic ... Malignancies (eg ... #differential #hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Clinical Presentation ... ecchymoses, mucosal bleeding ... hematopoietic stem cells ... number of CD34+ cells ... #oncology #hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
fever syndromes Clinical ... Fever is the main clinical ... with leukopenia, anemia ... Diagnosis #Management #Hematology ... #Rheumatology
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
Paradoxical spontaneous bleeding ... occlusions, as well ... skin necrosis • DIC ... Cryofibrinogenemia #diagnosis #rheumatology ... #hematology
Solitary Cell Plasmacytoma What? • Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) • In 3%
Solitary Cell Plasmacytoma ... plasmacytoma) Clinical ... • No CRAB - no anemia ... patients with EMD ... Diagnosis #Workup #Hematology
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