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diagnosis anemia aplastic blood oncology product reactions treatment activation antinxp2 antinxp2dm autoimmune dermatomyositis differential hemophagocytic hlh leukemia lymphohistiocytosis lysis macrophage
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis vs Tumor ... Leukostasis: • ... WBC >100k, + lab signs ... TLS #diagnosis #management ... #hematology
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
Illness Script Signs ... neutropenia • Mucosal bleeding ... Anemia #diagnosis #management ... #treatment #hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
IL-1 and IL-6, leading ... purpura to mucosal bleeding ... Petechial or purpuric rash ... #Diagnosis #Management ... #Hematology #Rheumatology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
night sweats, bleeding ... ↑ Can develop leukostasis ... syndrome: CNS manifestations ... • Tumor lysis syndrome ... #Leukemia #Hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Constitutional Syndromes ... ecchymoses, mucosal bleeding ... Constitutional Syndromes ... Anemia #oncology #hematology ... #diagnosis #management
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Overwhelming clinical syndrome ... Diagnosis: HLH signs ... Lymphohistiocytosis #diagnosis #management ... #treatment #hematology
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
maculopapular rash ... Injury (TRALI): Leading ... coagulopathy & ↑bleeding ... Transfusion #diagnosis #management ... #hematology #reactions
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
maculopapular rash ... Injury (TRALI): Leading ... coagulopathy & ↑bleeding ... Transfusions #diagnosis #management ... #hematology #reactions
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
(blue-purple) rash ... • Erythematous rash ... Dermatomyositis #diagnosis #management ... #rheumatology # ... dermatology
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
RP-ILD), dermato-rheumatologic ... Symptoms: • Gottron rash ... papules and Gottron sign ... ) • Shawl sign ... Myositis #Myopathy #rheumatology
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