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management pharmacology anticoagulation noac oncology algorithm cancer malignancy aptt bridging chemotherapy cyp3a4 dabigatran direct dosing dvt edoxaban inducers inhibitors interactions
Oral anticoagulant dosing and bridging for VTE - Dr. Joseph Shatzel @Clotmaster #VTE #DOAC #Bridging #Dosing #Oral
Oral anticoagulant ... and bridging for VTE ... #DOAC #Bridging ... #Dabigatran #Apixaban ... #Pharmacology #Hematology
NOAC / DOAC Pharmacology and Prescribing Cheat Sheet Novel (or Direct) Oral Anti-Coagulants • Rivaroxaban • Apixaban
Novel (or Direct) Oral ... Rivaroxaban • Apixaban ... #Prescribing #hematology ... management #Direct #Oral ... #AntiCoagulant
Patient risk stratification algorithm for the treatment of cancer-associated thrombosis. Currently, edoxaban and rivaroxaban are the only
algorithm for the treatment ... direct-acting oral ... anticoagulants ... #DOAC #VTE #Malignancy ... Anticoagulation #Management #Hematology
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 Treatment algorithm for VTE in Malignancy (A) Suggested treatment algorithm for symptomatic and incidental DVT or PE
for VTE in Malignancy ... risk of recurrent VTE ... DOAC, direct oral ... #DOAC #VTE #Malignancy ... Anticoagulation #Management #Hematology
DOAC Reversal Emergency surgery or urgent procedure Stop anticoagulant treatment; volume resuscitation and transfusion as needed Antidotes: • Apixaban,
procedure Stop anticoagulant ... treatment; volume ... Antidotes: • Apixaban ... #Oral #anticoagulant ... #hematology #management
Perioperative Management of DOACs Problem: ✖ Each year approximately 250,000 patients on chronic anticoagulation in North America
direct acting oral ... anticoagulants ... and procedural bleeding ... with a very low bleeding ... inhibitor) • Apixaban
(DOAC interactions) Cancer-treatment specific inducers (↑) and inhibitors (↓) of cytochrome p450 CYP3A4 and P-glycoprotein. DOACs are substrates
) Cancer-treatment ... thereby leading ... rivaroxaban, and apixaban ... Rivaroxaban and apixaban ... Chemotherapy #Oncology #Hematology
Effect of Direct Oral Anticoagulants on Hemostatic Tests Horizontal bars correspond to the approximate range of detectability
Effect of Direct Oral ... Anticoagulants ... , rixaroxaban, apixaban ... thrombin time #doac ... #hematology #laboratory
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