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Map of proliferative blood disorders. 

By Ariella Coler-Reilly @ariellastudies

#Algorithm #classification #proliferative #blood #disorders #leukemia #hematology #oncology
Map of proliferative ... blood disorders ... #disorders #leukemia ... #hematology #oncology ... #CLL #AML #Map
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
the peripheral blood ... Blast cells - Blood ... activity • ↓ LAP ... AML: Blast crises ... #Hematology #Oncology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
- History of bleeding ... plateletcount), peripheral blood ... not required in all ... However, it may ... Causes #Workup #hematology
Basophilia - Differential Diagnosis Framework

Basophils < 1% of the total white blood cell count
Basophils function similarly
the total white blood ... Myeloproliferative Disorders ... Chronic myeloid leukemia ... (CML) - associated ... Diagnosis #causes #hematology
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
Chronic Lymphocytic Leukemia ... lymphoproliferative disorders ... Lymphocytosis: Absolute blood ... Transform to DLBCL, PML ... workup #oncology #hematology
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
are a group of disorders ... are caused by bleeding ... • Hairy Cell Leukemia ... progression to AML ... Syndromes #diagnosis #hematology
Hematology Algorithms 

Anemia is described as a reduction in the proportion of the red blood cells.
Hematology Algorithms ... proportion of the red blood ... three peripheral blood ... that involves disorders ... < 13 may represent
Helpful Clinical Features in Evaluating Bleeding Disorders
Age of onset
 • Neonate - in 20% of haemophilias,
— haemophilias may ... Willebrand disease may ... relatives (if all ... #Bleeding #Disorders ... pediatrics #diagnosis #hematology
Cryofibrinogenemia Summary

Cryofibrinogenemia Epidemiology:
 • 40-70 years with a modest female predominance

Cryofibrinogenemia:
 • The precipitation of a
which can plug blood ... Paradoxical spontaneous bleeding ... may occur due to ... cryoglobulinemia Associated Disorders ... #hematology
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
ecchymoses, mucosal bleeding ... virus (EBV) • Leukemia ... symptoms that may ... result from low blood ... Anemia #oncology #hematology