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diagnosis product reactions algorithm anemia anticoagulation aplastic cancer causes chemotherapy coagulation dic disseminated inducers inhibitors interactions intravascular malignancy mds myelodysplasia
(DOAC interactions) Cancer-treatment specific inducers (↑) and inhibitors (↓) of cytochrome p450 CYP3A4 and P-glycoprotein. DOACs are substrates
(DOAC interactions ... thereby leading ... metabolization leading ... #Chemotherapy #Oncology ... #Hematology #Interactions
Treatment algorithm for VTE in Malignancy (A) Suggested treatment algorithm for symptomatic and incidental DVT or PE
at high risk of bleeding ... DOAC, direct oral ... #DOAC #VTE #Malignancy ... Anticoagulation #Management ... #Hematology #Oncology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Findings: • Bleeding ... ABO incompatible blood ... thrombopoietin deficiency ... causes #treatment #management ... #hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
ecchymoses, mucosal bleeding ... result from low blood ... Aplastic #Anemia #oncology ... #hematology #diagnosis ... #management
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
unusual bruising or bleeding ... or folic acid deficiency ... treatments • Copper deficiency ... Syndromes #diagnosis #hematology ... #oncology
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
recipients w/ IgA deficiency ... Injury (TRALI): Leading ... coagulopathy & ↑bleeding ... Transfusions #diagnosis #management ... #hematology #reactions
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
Blood Transfusion ... recipients w/ IgA deficiency ... coagulopathy & ↑bleeding ... Transfusion #diagnosis #management ... #hematology #reactions
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