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management coagulation differential product reactions table alkaline alp anemia aplastic atlas bruising causes chemotherapy comparison cyp3a4 deficiencies dic disseminated hemostasis
(DOAC interactions) Cancer-treatment specific inducers (↑) and inhibitors (↓) of cytochrome p450 CYP3A4 and P-glycoprotein. DOACs are substrates
inducers (↑) and inhibitors ... thereby leading ... metabolization leading ... #Chemotherapy #Oncology ... #Hematology #Interactions
Summary of Coagulation Deficiencies Inherited: • Hemophilia A - Deficiency of Factor VIII • Hemophilia B -
LMWH, warfarin, DOACs ... direct factor Xa inhibitors ... direct thrombin inhibitors ... table #comparison #diagnosis ... #hematology #deficiency
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
Bleeding and Bruising ... - Differential Diagnosis ... • Bleeding gums ... #Differential #Diagnosis ... #Hematology
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Red Blood Cell ( ... Microcytic - Iron-deficiency ... Liver diseases, Bleeding ... Morphology #Atlas #key #diagnosis ... #differential #hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Findings: • Bleeding ... ABO incompatible blood ... thrombopoietin deficiency ... #Coagulation #diagnosis ... treatment #management #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
the peripheral blood ... Blast cells - Blood ... blast cells - Blood ... #Leukemia #Hematology ... #Oncology #Diagnosis
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
are caused by bleeding ... or folic acid deficiency ... methyltransferase inhibitors ... Myelodysplastic #Syndromes #diagnosis ... #hematology #oncology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
ecchymoses, mucosal bleeding ... , CTLA4 deficiency ... result from low blood ... Aplastic #Anemia #oncology ... #hematology #diagnosis
Low Alkaline Phosphatase - Hypophosphatasia Is Low Alkaline Phosphatase Of Clinical Importance? ALP enzyme- Discovered in 1923 Low
Most cases diagnosed ... pyrophosphate: Inhibitor ... • blood collection ... Hyophosphatasia #hepatology ... #diagnosis
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
recipients w/ IgA deficiency ... Injury (TRALI): Leading ... coagulopathy & ↑bleeding ... #Transfusions #diagnosis ... #management #hematology
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