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differential hepatology management algorithm hepatitis lfts rheumatology abnormal amyloid amyloidosis chemistry comparison enzymes hellp hemophagocytic hlh icp infections infectiousdiseases injury
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
- Differential Diagnosis ... vein: Budd-chiari syndrome ... • Gilbert's syndrome ... RBC (hemolysis, bleeding ... #differential #diagnosis
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
of cholestatic disease ... disease: > 2 ... RBC (hemolysis, bleeding ... • Gilbert's syndrome ... #chemistry #diagnosis
Liver Disease in Pregnancy Intrahepatic Cholestasis of Pregnancy (ICP) • Onset/Trimester: 25-32 weeks • Typical clinical features:
Liver Disease in ... necrosis HELLP Syndrome ... of Pregnancy (AFLP ... #differential #diagnosis ... #icp #HELLP #AFLP
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation ... Clinical Presentation ... Fever is the main clinical ... thrombocytopenia • Liver ... #Syndrome #Diagnosis
Abnormal liver function tests algorithm. This figure details the initial response to abnormal liver blood tests.
presence of metabolic syndrome ... ALP, alkaline phosphatase ... disease; AST, aspartate ... disease; T2DM, ... mellitus; USS, ultrasound
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
: Overwhelming clinical ... syndrome associated ... excessive macrophage activation ... age, however the disease ... lymph node, or liver
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Diagnosis: • Dry ... salivary ducts Clinical ... vasculitis: 10%-16% Liver ... Nephrogenic DI Hematologic ... phenomenon (16%) MSK
Amyloidosis - Summary Group of disorders associated with extracellular deposition of fibrils formed from low-molecular-weight proteins in
Clinical suspicion ... the extent of disease ... failure • GI bleeding ... Inflammation → Macrophage activation ... imaging of liver
Nontuberculous Mycobacteria (NTM) Infections Mycobacterial species other than those belonging to the Mycobacterium tuberculosis complex and
Lady Windermere Syndrome ... : • Syndrome of ... Hematologic malignancy ... (elevations of liver ... • Clinical (Symptoms
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