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systemic pruritus thrombocytosis classification cold elevatedmcv extravascular hemolysis hodgkins intravascular lymphoma macrocytic macrocytosis mds myelodysplasia naildisorders nonpalpable palpable platelets primary
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Disease (CAD): ... Agglutinin Syndrome ... Diagnosis: • hemolytic ... #disease #hemolytic ... #anemia #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Diagnosis Algorithm ... #Anemia #Differential ... #Diagnosis #Algorithm ... #workup #hematology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Diagnosis Secondary ... malignancies • Anemia ... , hemolysis, hemorrhage ... #Diagnosis #Causes ... #hematology #secondary
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
. primary cold agglutin ... disorders, Mycoplasma ... G6PD deficiency) ... #differential # ... diagnosis #hematology
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes == Primary Skin Lesions == Macules /
Differential Diagnosis ... syndrome Psychiatric ... Pruritus #primary #secondary ... #dermatology #Differential ... #Diagnosis #Algorithm
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... Diagnosis Algorithm ... Syndromes Macrocytosis ... #Diagnosis #Algorithm ... #Causes #Hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
DIC/TTP/HUS - Hemolytic ... anemia - Splenomegaly ... necrosis) • VIT K deficiency ... #Diagnosis #hematology ... #nonpalpable #dermatology
Pruritus - No Primary Skin Lesion - Differential Diagnosis Algorithm Blood Glucose: • Diabetes Mellitus Liver Function Tests/Enzymes:
Diagnosis Algorithm ... syndrome Psychiatric ... #dermatology #Differential ... #Diagnosis #Algorithm ... #causes
Nail Disorders secondary to Systemic Diseases Nail Fold Abnormality • SLE • Scleroderma • Dermatomyositis Koilonychia - Spoon-shaped
Nail Disorders secondary ... • Nephrotic syndrome ... #dermatology #Differential ... #Diagnosis #Algorithm ... #causes
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
Diagnosis Algorithm ... → Refer to hematology ... , deficiency anemia ... #Diagnosis #Algorithm ... #hematology
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