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oncology causes hemolytic lymphocytic erythematosus gap hemeonc hemodialysis lupus monoclonal paraproteinemias platelet protein proteingap pruritus sle systemic testing thrombocytopenia thrombocytosis
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
(CAD) 2. ... Agglutinin Disease ... anemia • Cold ... #agglutinin #disease ... #hematology #diagnosis
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Diagnosis Algorithm ... Artifact (redo CBC ... Myelogenous Leukemia ... #Diagnosis #Algorithm ... #Causes #Hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Diagnosis Algorithm ... Agglutination - Cold ... agglutinins disease ... Diagnosis #Algorithm ... #workup #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Lymphocytosis on CBC ... • Neutropenia, anemia ... #Leukemia #diagnosis ... #workup #oncology ... #hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
- Differential ... Diagnosis and Workup ... decreased PLT count: CBC ... changes), high MCV anemia ... #Workup #hematology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Leukemia (CLL) ... in adults • Disorder ... Vmphocytosis on routine CBC ... #hematology #hemeonc ... #diagnosis #management
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... cancers, HCC, renal ... gastric tumors • Hematology ... anemia • Other ... #diagnosis #hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
• CAD APLA/LAC ... : • Renal artery ... titers > 1:80 • CBC ... with Lupus: • Chronic ... #Rheumatology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Autoantibodies: • WAIHA • CAD ... (-) hemolytic anemia ... due to cold IgG ... vascular beds-renal ... Paraproteinemias #Hematology
Management of Pruritus in Patients with Chronic Kidney Disease Pruritus with no primary lesions - differential diagnosis:
Patients with Chronic ... diagnosis: • ... Renal pruritus ... #Management #Nephrology ... #CKD
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