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Humoral Immunity - Pathogenesis and Clinical Findings Antigens (Ag) are produced from pathogens (bacteria, viruses, fungi, parasites)
Pathogenesis and Clinical ... Ag-presenting cells ... CD4+ helper T cells ... or plasma cells ... ) • Plasma cells
Schistocytes can assume a shape resembling natural or man-made objects such as arrowheads, fish, collar buttons,
point to helmet cells ... are a teardrop cell ... , 2 blister cells ... ), and 2 burr cells ... #Clinical #Path
Type IV Hypersensitivity: Pathogenesis and clinical findings Definition: Unique because it is entirely T-Cell mediated; exposure to
Pathogenesis and clinical ... is entirely T-Cell ... allergen-specific T-Cell ... exposure, because T-Cell ... harmful -> Th Cells
Type II Hypersensitivity: Pathogenesis and clinical findings Definition: When antigens bind to the body's cell surfaces, forming
Pathogenesis and clinical ... to the body's cell ... receptor on body cell ... -> B-Cells with ... foreign -> B-cells
Sickle cells These photos show sickle cells on peripheral blood smears. In the left photo target cells
Sickle cells These ... photos show sickle cells ... photo, target cells ... trait do very well clinically ... #Clinical #Path
Anaplastic large cell lymphoma, ALK+ Clinical • First 3 decades of life, M>F • Often nodal +
Anaplastic large cell ... lymphoma, ALK+ Clinical ... subtle • Small cell ... hof (Hallmark cells ... ) • Donut cells
Inflammatory Cascade: Pathogenesis and Clinical Findings Continued Innate Immunity • Phagocytosis: (main mechanism) neutrophils and macrophages engulf
Pathogenesis and Clinical ... Natural Killer Cells ... • Humoral: (B cell ... : (T cell response ... and cytotoxic cell
Peripheral Blood Smear Analysis Hypochromia Megaloblastic Anemia Schistocytes: Microangiopathic hemolytic anemia (e.g. DIC, TTP, HUS) Microspherocytes: Autoimmune hemolytic anemia Sickled red
anemia Sickled red cells ... : Sickle cell disease ... Bite cells: G6PD ... interpretation #clinical
Red cell autoagglutination is the process whereby red cells clump together forming aggregates. This is seen
Red cell autoagglutination ... process whereby red cells ... individual’s red blood cells ... #Clinical #Path
Red cell autoagglutination is the process whereby red cells clump together forming aggregates. This is seen
Red cell autoagglutination ... process whereby red cells ... individual’s red blood cells ... #Clinical #Path
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