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diagnosis hematology oncology blood product reactions treatment anemia differential mds myelodysplastic prs pulmonary renal syndrome syndromes transfusion transfusions
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
dys- (abnormal) -plastic ... old, ~10,000 new cases ... risk-stratification • Risks: infection ... transformation to acute ... leukemia Management
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Marrow (Toxic injury ... and petechiae Causes ... Idiopathic • Infections ... ) • Leukemia ... #diagnosis #management
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
APML, CLL Acute ... Malaise, bleeding, infections ... : Blast crises ... pain, bleeding, infections ... #Hematology #Oncology
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
quantify renal injury ... Other tests: • CT ... confirm DAH, r/o infection ... seen on chest CT ... differential #diagnosis #management
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
• Acute Hemolytic ... Transfusion Related Acute ... Lung Injury (TRALI ... due to marrow aplasia ... Transfusion #diagnosis #management
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
- Acute Hemolytic ... Transfusion Related Acute ... Lung Injury (TRALI ... due to marrow aplasia ... Transfusions #diagnosis #management
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