11 results
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
→ Refer to hematology ... Rebound effect from treatment ... Metastatic cancer, Lymphoma ... , Vasculitides, ... #Algorithm #hematology
IgG4-Related Disease
Clinical history:  Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor
4 phenotypes:
 •
Retroperitoneum and aorta ... concentration PET-CT ... No necrosis, No vasculitis ... • "Reactive lymphoid ... #rheumatology
Hodgkin's Lymphoma Overview

Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
• History of EBV ... Mediastinal mass) • CT ... physical exam, CT ... Treatment • Early ... #hematology #oncology
Sjogren's Syndrome Overview

Epidemiology:
• F > M: 9:1
• 5-6th Decades (can be any age)

Autoimmune exocrinopathy multisystemic disease
) • Cutaneous vasculitis ... Hematologic: ... : 2% Systemic Vasculitis ... Adenocarcinoma Treatment ... Sjogrens #Syndrome #Rheumatology
CNS Infection in HIV / AIDS - Differential Diagnosis Framework

Principles of HIV-Associated CNS Opportunistic Infections:
 •
lymphoma ... Antimicrobial treatment ... enhancement on CT ... Lymphoma: • CD4 ... effect/Edema • EBV
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
- Differential Diagnosis ... glomerulonephritis) • Anti-GBM ... < 30 years - Aorta ... • ANA (Suggest CTD ... #rheumatology #
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
→Activation of CD8 ... Hodgkin, T-cell lymphoma ... , B-cell lymphoma ... #management #treatment ... #summary #rheumatology
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Cryoglobulins (Vasculitic ... autoimmune disorder or lymphoid ... - Monoclonal - Lymphoid ... - Mycoplasma, EBV ... hemolytic #anemia #hematology
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
, small-vessel vasculitis ... ) Differential Diagnosis ... Ischemia, Leukemia, Lymphoma ... Arthritis, AS Treatment ... signs #symptoms #rheumatology
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Diagnosis Framework ... < 30 years • Aorta ... Arteritis): • Aorta ... pain and GN Anti-GBM ... #Rheumatology