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hematology management differential treatment coagulation bleeding causes hit induced nutrition pt thrombocytopenia abnormal algorithm anemia aptt comparison folate oncology pathophysiology
Prothrombin Time (PT) and Partial Thromboplastin Time (PTT) Prothrombin Time (PT) - Often Elevated in: • Vitamin
• Vitamin K deficiency ... • Factor VII deficiency ... elevated in: • Heparin ... Thromboplastin #laboratory #hematology ... #diagnosis
Diagnosing Vitamin B12 and/or Folate Deficiency It turns out that simply measuring serum levels of B12 or
Diagnosing Vitamin ... inadequate to diagnosis ... with low B12 stores ... #Diagnosis #Nutrition ... #Hematology #ComparisonTable
Summary of Coagulation Deficiencies Inherited: • Hemophilia A - Deficiency of Factor VIII • Hemophilia B -
Hemophilia A - Deficiency ... Hemophilia B - Deficiency ... Medications - Heparin ... table #comparison #diagnosis ... #hematology #deficiency
Approach to suspected Heparin-Induced Thrombocytopenia (HIT) • Suspected HIT Algorithm • "4 T's" clinical probability score:
Approach to suspected Heparin-Induced ... Algorithm • "4 T's" clinical ... NephPrasad #Heparin ... Thrombocytopenia #HIT #hematology ... #diagnosis #4Ts
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Differential Diagnosis ... Pre-analytical cause (e.g. heparin ... thrombin inhibitors, heparin ... Prolonged #Causes #diagnosis ... #differential #hematology
Treatment of Thrombotic Thrombocytopenic Purpura (TTP) Diagnosis of TTP: • Rare and severe, ADAMTS13 deficiency • Autoimmune
Purpura (TTP) Diagnosis ... severe, ADAMTS13 deficiency ... soon as TTP is diagnosed ... PLEX and RTX • Short-term ... #hematology
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
unfractionated heparin ... cause e.g. heparin ... thrombin inhibitors, heparin ... Prolonged #Causes #diagnosis ... #differential #hematology
Iron Deficiency Anemia (IDA) Tests: • MCV/RBC - RBC ↓ in proportion to the ↓ in hemoglobin
Iron Deficiency ... total body iron stores ... DharSaty #Iron #Deficiency ... #ferritin #Fe #diagnosis ... #hematology
Etiologies of Folate Deficiency • Decreased dietary intake - uncommon in this era • Increased requirements
Etiologies of Folate Deficiency ... mobilize folate stores ... depleted tissue stores ... #differential #diagnosis ... #hematology #nutrition
Our approach to the diagnosis and initial management of patients with suspected HIT. Our approach is
approach to the diagnosis ... based primarily on clinical ... Estimates of the clinical ... #Hematology #HIT ... #Heparin #Induced
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