287 results
NOAC / DOAC Pharmacology and Prescribing Cheat Sheet
Novel (or Direct) Oral Anti-Coagulants
 • Rivaroxaban
 • Apixaban
NOAC / DOAC Pharmacology ... #NOAC #DOAC #Pharmacology ... #Prescribing #hematology
Pharmacokinetic Characteristics and Primary Routes of Clearance of Oral Anticoagulant Agents

Warfarin - 100% Hepatic, 0% Renal
Apixaban
Primary Routes of Clearance ... Hepatic, 35% Renal #DOAC ... #NOAC #Metabolism ... #Pharmacology #Clearance
DOAC: Cheat Sheet - Atrial Fibrillation, VTE Prophylaxis, VTE and Renal Dosing

Renal Dosing:
Apixaban (25% renal clearance):
DOAC: Cheat Sheet ... Apixaban (25% renal clearance ... @Bloodman #DOAC ... Anticoagulation #Hematology ... Dabigatran #Edoxaban #NOAC
Switching Between Anticoagulants and DOACs
VKA, Dabigatran, Rivaroxaban, Apixaban, Edoxaban, Betrixaban, DOAC, Parenteral anticoagulant

DOI: 10.1161/JAHA.120.017559

#Anticoagulants #DOACs #anticoagulation
Anticoagulants and DOACs ... Edoxaban, Betrixaban, DOAC ... Anticoagulants #DOACs ... anticoagulation #Switching #hematology
Anticoagulants Common Reversal Agents
 - Warfarin (Coumadin) → Vitamin K (Phytonadione), 4-factor PCC (Kcentra)
 - Heparin/LMWH
anticoagulation #doac ... #noac #pharmacology ... #hematology #reversal
Patient risk stratification algorithm for the treatment of cancer-associated thrombosis.

Currently, edoxaban and rivaroxaban are the only
stratification algorithm ... anticoagulants (DOACs ... filtration rate; DOAC ... #Cancer #Algorithm ... Anticoagulation #Management #Hematology
Perioperative Management of DOACs
Problem:
 ✖ Each year approximately 250,000 patients on chronic anticoagulation in North America
Management of DOACs ... anticoagulants (DOACs ... recent creatinine clearance ... determine timing of DOAC ... postoperative #DOAC
(DOAC interactions) Cancer-treatment specific inducers (↑) and inhibitors (↓)
of cytochrome p450 CYP3A4 and P-glycoprotein.

DOACs are substrates
(DOAC interactions ... DOACs are substrates ... metabolization of DOACs ... concentrations of DOACs ... Chemotherapy #Oncology #Hematology
Coagulation Cascade and Anticoagulant Sites of Action

- Amy Chung, MD, MSc https://twitter.com/AmyChung

#AntiCoagulation #Cascade #Anticoagulants #Medications #Pharmacology
Pathophysiology #Mechanisms #DOAC ... #Hematology
Oral anticoagulant dosing and bridging for VTE

- Dr. Joseph Shatzel @Clotmaster 

#VTE #DOAC #Bridging #Dosing #Oral
Clotmaster #VTE #DOAC ... #Pharmacology #Hematology