61 results
Systemic Lupus Erythematosus (SLE): Pathogenesis

 • Genetic factors (Mutations in HLA- DR2/HLA-DR3 genes, complement genes, cytokine
Systemic Lupus Erythematosus ... HLA-DR3 genes, complement ... self-antigens, activating complement ... Systemic #Lupus #Erythematosus
Summary table of types of hypersensitivity reactions. 
Type 1
 - Mediators: lgE
 - Antigen Form: Soluble
Summary table of ... antigens, leading to complement ... they activate complement ... Systemic lupus erythematosus ... types #allergy #table
Causes of Hypocomplementemia - CHAMPS Mnemonic
C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis
H - Heavy Chain deposition
Systemic Lupus Erythematosus ... Hypocomplementemia #Low #Complement
Hypersensitivity Types and Their Mechanisms
Type I - lgE - Soluble antigen
 - Allergen-specific lgE antibodies bind
antigen, leading to complement ... Complement activation ... systemic lupus erythematosus ... Diagnosis #Reactions #Table
Crusted Scabies - Physical examination now revealed a generalized erythematous and scaly rash with intense hyperkeratotic
a generalized erythematous ... C) #Clinical #Derm
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... 80% - Low complement ... lupus #Systemic #Erythematosus
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Systemic Lupus Erythematosus ... anti-Smith Ab, low complements ... cutaneous lupus erythematosus ... (ACLE) • Erythematous ... RNP antibodies, Complement
Ecthyma Gangrenosum - A physical examination revealed a 2-cm hemorrhagic patch with an erythematous border (Panel
patch with an erythematous ... #Clinical #Derm
African Trypanosomiasis - The examination was notable for the two erythematous lesions, each measuring 3 to
notable for the two erythematous ... B) #Clinical #Derm
Thrombotic Microangiopathies - Primary Thrombotic Microangiopathy (TMA) - Differential Diagnosis Table

 • Thrombotic Thrombocytopenic Purpura (TTP)
Differential Diagnosis Table ... HUS (aHUS) - Complement-mediated