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diagnosis differential vasculitis classification dermatology cryofibrinogenemia cryoglobulins disorders eosinophil eosinophilia glomerulonephritis mds myelodysplasia myelodysplastic oncology petechiae petechial physicalexam progressive rapidly
Skin Ulcers by Etiology - Differential Diagnosis Algorithm Physical: • Trauma • Pressure • Radiation Vascular: • Arterial
Skin Ulcers by Etiology ... Differential Diagnosis Algorithm ... Thalessemia • Cryoglobulinemia ... Viral - Herpes simplex ... #causes
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
pathophysiologic causes ... immunofluorescence Immune Complex ... Lupus Nephritis, Cryoglobulinemia ... differential #diagnosis #algorithm ... #rheumatology
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
vasculitis, sepsis or cryoglobulinemia ... cryoglobulins • Negative causes ... Calciphylaxis • Cryoglobulinemia ... Cryofibrinogenemia #diagnosis #rheumatology ... #hematology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
deposit of immune complexes ... • They can cause ... - Purpura - Skin ... Cryoglobulins Cause ... classification #rheumatology
Eosinophil Disorders Testing Algorithm INDICATIONS FOR TESTING: • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
Disorders Testing Algorithm ... evaluation or workup ... 1,500 cells/µL Workup ... symptoms (eg, skin ... Differential #diagnosis #hematology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tracts Immune Complex ... tract, and often causes ... ANCA +MPO) • Cryoglobulinemic ... Low levels mixed cryoglobulinemia ... differential #diagnosis #rheumatology
Causes of Petechial Rash - Differential Diagnosis Algorithm Pinpoint areas (less than 2 mm) of hemorrhage, which
Causes of Petechial ... deficiency Work ... Up: • Complete ... cryoglobulins • Skin ... #Causes #dermatology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Purpura, ischemic skin ... pauci-immune GN Immune Complex ... tract, and often causes ... / ANCA + MPO) Cryoglobulinemic ... Differential #Diagnosis #Rheumatology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... just beneath the skin ... that are caused ... Workup: • Complete ... Syndromes #diagnosis #hematology
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