14 results
Pulmonary Renal Syndrome

Definition: Diffuse alveolar hemorrhage + Glomerulonephritis
Presentation (Pulmonary and renal manifestations can occur weeks apart):
Pulmonary Renal ... symptomatology Differential ... ANCA-positive vasculitis ... Cryoglobulinemia) • Immune Complex ... #differential #
Petechiae/Purpura - Diagnostic Algorithm. Pathophysiology: 1) Represent the passage of erythrocytes from the intravascular to extravascular
Pathophysiology: ... trauma, infection, vasculitis ... affected (commonly renal ... and pulmonary ... Palpable #Algorithm #Differential
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
three primary pathophysiologic ... causes differentiated ... immunofluorescence Immune Complex ... With associated pulmonary ... #differential #
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
- Differential ... and renal abnormalities ... tracts Immune Complex ... tract, and often causes ... • Urinalysis (Renal
Pulmonary Renal Syndromes - OnePager Summary
Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
Pulmonary Renal ... Autoimmune ANCA vasculitis ... palpable purpura 2/2 vasculitis ... Goodpasture's cause ... #differential #
IgA Vasculitis – Henoch Scholein Purpura: Pathogenesis and Clinical Findings

 - Infectious Agents - 50% have
adhesion of IgA complexes ... Formation of immune complexes ... Intussusception - Renal ... nephritic syndrome, renal ... HenochScholeinPurpura #Pathophysiology
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Vasculitis - Differential ... and renal abnormalities ... Vasculitis Differential ... pauci-immune GN Immune Complex ... tract, and often causes
Polyarteritis Nodosa (PAN): Pathogenesis and Clinical Findings

Medical Comorbidities Malignancies (most commonly hairy-cell leukemia)
Immunogenetic Predisposition: patient is
antigen-antibody complexes ... Viral replication causes ... Hypertension - Renal ... PolyarteritisNodosa #Pathophysiology ... Signs #Symptoms #Vasculitis
Hypochloremia - Differential Diagnosis Algorithm

Cause - Decreased Intake:
 • Low salt in diet
 • Exclusive D5W
Hypochloremia - Differential ... - Diarrhea • RENAL ... gas transport, renal ... homeostasis is complex ... Diagnosis #Algorithm #Pathophysiology
Clinical Classification of Pulmonary Hypertension

1. Pulmonary arterial hypertension from pulmonary vasculopathy
Idiopathic pulmonary arterial hypertension
Heritable gene mutations
Pulmonary arterial ... neurofibromatosis, vasculitis ... mediastinitis, chronic renal ... Classification #Diagnosis #Differential ... #Causes