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hematology algorithm differential macrocytic oncology aafp b12 cancer cardiology causes chronic cll cobalamin deficiency folate folicacid gap globulin homocysteine hypophosphatemia
Algorithm for the evaluation of macrocytic anemia. (RBC = red blood cell; MMA = methylmalonic acid.) Physicians
Algorithm for the evaluation ... RBC = red blood cell ... ; MMA = methylmalonic ... by ordering a peripheral ... #Diagnosis #Macrocytosis
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Diagnosis: • ... cytometry • Peripheral ... • Neutropenia, anemia ... ’s lymphoma or acute ... #workup #oncology
Anemia Diagnostic Algorithm Mean corpuscular (cell) volume (MCV): Average RBC size. Under 80 = microcytic. Between 80-95
Anemia Diagnostic ... Mean corpuscular (cell ... immature RBCs) in peripheral ... High in acute blood ... #Workup #Hematology
Hypophosphatemia - Differential Diagnosis Algorithm Appropriately Low Kidney Phosphate Excretion: • Decreased GI Absorption: Chronic Diarrhea, Antacids,
Absorption: Chronic Diarrhea ... Refeeding Syndrome, Acute ... Fanconi Syndrome, (MM ... Carboxymaltose, CAR-T cell ... nephrology #phosphorus #workup
Vitamin B12 (Cobalamin) Deficiency Etiology: • Vit B12 - aka cobalamin. Present in foods derived from animal
tongue), abd pain, diarrhea ... total body stores Evaluation ... findings, HSM, LN, peripheral ... - Elevated MMA ... consider other diagnosis
Widened Pulse Pressure - Differential Diagnosis and Pathophysiology Pulse pressure is the difference between the systolic blood
defined as >100 mm ... Pregnancy • Well-conditioned ... iron deficiency anemia ... arteriosus or peripheral ... : • Acute Coronary
Solitary Cell Plasmacytoma What? • Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) • In 3%
ridging around the periphery ... Diagnosis? ... • No CRAB - no anemia ... Evaluation? ... #Workup #Hematology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... first step in evaluation ... myeloma • Plasma cell ... anemia • Other ... #differential #diagnosis
Myelodysplastic syndromes current treatment algorithm 2018. From Blood Cancer Journal, Published 24 May 2018 Myelodysplastic syndromes (MDS) are
risk of clonal evolution ... to acute myeloid ... median age at diagnosis ... disease tolerate anemia ... with repeated red cell
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