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diagnosis vasculitis differential management behcet classification cryofibrinogenemia cryoglobulinemic cutaneous dermatology disease erythematosus hematology lupus signs sjogrens skin symptoms systemic vasculitides
Diagnosis of Cryoglobulinemia Vasculitis 1) Presence of cryoglobulin Circulating immunoglobulins that precipitate with cold temperature and dissolve
l) : Vascular occlusion ... Hyperviscosity syndrome ... • Arthralgia, arthritis ... • Renal Involvement ... Vasculitis #Diagnosis #Rheumatology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
ulceration • Ocular ... disease (SVC/IVC occlusion ... Oral aphthae : SLE ... : SLE, Reactive ... signs #symptoms #rheumatology
Vasculitis Involving the Skin - Differential Diagnosis Framework Primary: 50% Cutaneous Vasculitis: Leukocytoclastic Vasculitis Secondary: CTD: SLE, RA
Secondary: CTD: SLE ... Urticarial/LCV) - Cryoglobulinemic ... IgM deposits • Nodular ... Disease • Cogan syndrome ... #dermatology #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
ANCA +MPO) • Cryoglobulinemic ... reactions, and vaso-occlusive ... Low levels mixed cryoglobulinemia ... vasculitis, and SLE ... differential #diagnosis #rheumatology
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
pulmonary emboli, and ocular ... thrombi including retinal ... and/or venous occlusions ... Antiphospholipid syndrome ... Cryofibrinogenemia #diagnosis #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
, inflammatory arthritis ... Erythematous, macular ... Non-autoimmune rheumatologic ... APLA/LAC: • Renal ... Erythematosus #Diagnosis #Rheumatology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
pulmonary and renal ... diseases, such as SLE ... reactions, and vaso-occlusive ... / ANCA + MPO) Cryoglobulinemic ... Differential #Diagnosis #Rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
overlaps with RA, SLE ... gland) biopsy • Ocular ... Vasculitis: • 7%, Cryoglobulinemia ... Arthralgia and Arthritis ... #Rheumatology #
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