Diagnosis of Cryoglobulinemia Vasculitis 1) Presence of cryoglobulin Circulating immunoglobulins that precipitate with cold temperature and dissolve with warming. Variable levels not related to clinical severity. Cryoglobulins are characterized into 3 types 2) Vasculitis with cryoglobulin immune deposits affecting small vessels (capillaries, venules, or arterioles) MONOCLONAL CRYOGLOBULINEMIA (type l) : Vascular occlusion >> vasculitis • Raynaud phenomenon • Ulcers, distal necrosis • Pain and swelling in the extremities • Hyperviscosity syndrome MIXED CRYOGLOBULINEMIA (types II and Ill) • Vascular purpura +++ • Peripheral neuropathy • Arthralgia, arthritis • Renal Involvement Dr. Benjamin Terrier @ https://twitter.com/TerrierBen #Cryoglobulinemia #Vasculitis #Diagnosis #Rheumatology #Cryoglobulinemic
