5 results
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
ATRA treatment Pathophysiology ... organ dysfuxtion, ICU ... Differentiation #Syndrome #APML ... #diagnosis #management ... #hematology #oncology
Cullen's sign. Lipase 1,781. Bruising in the skin around the umbilicus. This sign is named after
conditions that cause ... Pathophysiology: ... pregnancy, or other causes ... #cullensign #em ... peritonitis #IM #FM #ICU
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... of emergency, ICU ... inhibitors under evaluation ... #management #treatment ... #summary #rheumatology
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
high WBC count cause ... - ACS, AKI, acute ... WBC >100k, + lab signs ... Syndrome #TLS #diagnosis ... #management #hematology
It is important to recognize Acute Decompensated Heart Failure (ADHF) as more than just simply a
important to recognize Acute ... are excellent at evaluating ... the determined cause ... #algorithm #management ... #criticalcare #icu