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diagnosis hepatology differential management acute autoimmune chemistry chronic failure gap gastroenterology globulin hepatitis hepatorenal hrs interpretation lfts nephrology protein proteingap
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... months without treatment ... disease, liver ... Injury (DILI) ... #Cirrhosis #Hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
ALF): • Liver ... of cholestatic disease ... disease: > 2 ... hepatitis: < 1 • Cirrhosis ... #differential #Hepatology
Autoimmune Hepatitis Clinical Presentation - Highly variable clinical presentation, from subclinical disease to acute liver failure. -
from subclinical disease ... to acute liver ... hepatocellular pattern of liver ... injury, though ... regarding need for treatment
Hepatorenal Syndrome (HRS) Definition: • Functional, potentially reversible kidney impairment. • Occurs in advanced liver disease: cirrhosis, severe alcoholic
disease: cirrhosis ... hepatitis, or acute ... sympathetic + ADH ... Treatment Overview ... transplant evaluation
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... first step in evaluation ... Sarcoidosis) • Liver ... disease: Cirrhosis ... inflammation (acute
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