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diagnosis differential lupus management rheumatology algorithm druginduced oncology petechiae rash sle comparison disorders erythematosus leukemia mds myelodysplasia myelodysplastic nonpalpable physicalexam
Petechial/Purpuric Rashes- THE ALGORITHMIC APPROACH These rashes can be especially challenging and are associated with devastating differential
purpura presents in thrombocytopenic ... require emergent evaluation ... coagulopathy (DIC ... to have thrombocytopenia ... #Diagnosis #Dermatology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Causes of Thrombocytopenia ... Diagnosis and Workup ... History of bleeding (petechiae ... - Bone marrow evaluation ... #Workup #hematology
Causes of Petechial Rash - Differential Diagnosis Algorithm Pinpoint areas (less than 2 mm) of hemorrhage, which
Causes of Petechial ... hemostasis: - Thrombocytopenia ... • Extremes of age ... deficiency Work ... #dermatology #physicalexam
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
• Immunologic Workup ... : - ANA > ... 100,000, Typically Age ... • Immunologic Workup ... comparison #table #rheumatology
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
100,000, Typically Age ... of SLE versus DIL ... • Immunologic Workup ... : - ANA > ... Positive in 60-80% of cases
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... (petechiae) • ... with isolated del ... Workup: • Complete ... Syndromes #diagnosis #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
-> AML: Blast crises ... Significant ↓ PLT: Petechiae ... infiltrates (anemia, thrombocytopenia ... Fibrinolysis & DIC ... #Leukemia #Hematology
Drug Induced Lupus (DIL) • Epidemiology: -10% of all lupus cases, drug-dependent, 4:1 to 1:1 F:M
thiazidic, PPI, ACE ... • Immunologic Workup ... : - ANA > ... • Evolution: ... #rheumatology #
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