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diagnosis hepatology lupus management rheumatology algorithm druginduced sle ascites cholangitis comparison dil disorders erythematosus gap globulin hepatitis injury lfts liver
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
Primary Biliary ... intralobular bile ducts causes ... bile ducts Differential ... cholangitis #diagnosis #workup ... #hepatology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Platelet Disorders - Differential ... Diagnosis and Workup ... function test, ANA ... - Bone marrow evaluation ... #Workup #hematology
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Liver Enzymes - Differential ... disease US — Normal ... Infiltrative • Cirrhosis ... Duct Stone • Biliary ... Diagnosis #Algorithm #Causes
Ascites - Diagnostic Approach and Differential Diagnosis The most common causes: cirrhosis, malignancy and heart failure. Approx
The most common causes ... more than one cause ... smear/culture/ADA ... concentration (bowel or biliary ... Jcortesizaguirr #Ascites #workup
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
- CRP: Usually normal ... • Immunologic Workup ... : - ANA > ... Positive in 60-80% of cases ... management of SLE • Evolution
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
• Immunologic Workup ... : - ANA > ... Discontinuation of causal ... • Immunologic Workup ... comparison #table #rheumatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Liver Injury - Differential ... Algorithm Vascular Causes ... function may be abnormal ... hepatitis: < 1 • Cirrhosis ... injury #hepatitis #differential
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
TTP - Laboratory Evaluation ... decrease in most cases ... WBC count and differential ... ThromboticThrombocytopenicPurpura #Diagnosis #Workup ... #Hematology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... first step in evaluation ... Liver disease: Cirrhosis ... chain assay • An abnormal ... Gap #ProteinGap #differential
Drug Induced Lupus (DIL) • Epidemiology: -10% of all lupus cases, drug-dependent, 4:1 to 1:1 F:M
CRP - Usually normal ... • Immunologic Workup ... : - ANA > ... Discontinuation of causal ... cutaneous-DIL • Evolution
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