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diagnosis rheumatology differential management ana antibodies antinuclear druginduced erythematosus patterns systemic approach classification comparison dil joint laboratory msk pain rheumatic
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Juvenile Idiopathic Arthritis ... • Rheumatic Diseases ... : Lupus (SLE), Systemic ... Arthritis, Sjögren ... #patterns #rheumatology
ANA Patterns and Associated Rheumatic Diseases: • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
Associated Rheumatic ... Diseases: • Homogeneous ... connective tissue disease ... Juvenile Idiopathic Arthritis ... #patterns #rheumatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Constitutional symptoms, Arthritis ... • Immunologic Workup ... • Immunologic Workup ... Chronic disease ... #table #rheumatology
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
• Immunologic Workup ... : - ANA > ... • Evolution: ... Chronic disease ... Management #Summary #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... , inflammatory arthritis ... ANCA-associated vasculitis, rheumatoid ... Malignancy (e.g. hematologic ... vein thrombosis Hematologic
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Rheumatology Workup ... Diseases • Septic ... joint • Systemic lupus ... #Disease #Rheumatoid ... #workup #diagnosis
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
< 30 years - Aorta ... branches • GCA: - Aorta ... Diagnosis: Systemic rheumatic ... as systemic lupus ... vasculitis, and SLE
Approach to Joint Pain - Diagnostic Framework 1) Chronicity 2) Inflammatory vs Non-Inflammatory 3) Number of Joints Involved 1) Chronicity:
bacterial), acute rheumatic ... ), RA, crystal disease ... spondyloarthropathies, lupus ... Chronic = RA, SLE ... #approach #workup
Drug Induced Lupus (DIL) • Epidemiology: -10% of all lupus cases, drug-dependent, 4:1 to 1:1 F:M
Constitutional symptoms, Arthritis ... is rare in DIL, SCLE-DIL ... • Immunologic Workup ... : - ANA > ... #DIL #rheumatology
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