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diagnosis management lupus druginduced summary comparison differential disorders erythematosus hemophagocytic hlh lymphohistiocytosis mds myelodysplasia myelodysplastic oncology polychondritis relapsing syndromes systemic
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
, SCLE-DIL (terbinafine ... • Immunologic Workup ... • Immunologic Workup ... life-threatening • Treatment ... comparison #table #rheumatology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Diagnosis and Workup ... function test, ANA ... (e.g., SLE), anti-phospholipid ... - Bone marrow evaluation ... #Workup #hematology
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
versus DIL • ... • Immunologic Workup ... life-threatening • Treatment ... • Evolution: ... Management #Summary #rheumatology
Drug Induced Lupus (DIL) • Epidemiology: -10% of all lupus cases, drug-dependent, 4:1 to 1:1 F:M
, SCLE-DIL (terbinafine ... • Immunologic Workup ... : - ANA > ... • Evolution: ... #rheumatology #
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Fibrinogen level, ↑ sIL ... Autoimmune diseases: SLE ... Treatment: • ... inhibitors under evaluation ... #summary #rheumatology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... skin that are caused ... with isolated del ... Workup: • Complete ... Syndromes #diagnosis #hematology
Relapsing Polychondritis What is it? Recurrent inflammation of the cartilage in the body (Autoimmune disorder) Who? • Most frequently: 40
Large vessels (aorta ... such as: • SLE ... Nonspecific ↑ ESR, CRP, ANA ... affected tissue Treatment ... Polychondritis #rheumatology
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