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management rheumatology hematology adultonset blood differential product reactions activation adult algorithm central criteria dermatology macrophage major mas minor peripheral syndrome
Adult-Onset Still's Disease (AOSD) Rare inflammatory disorder of unknown etiology, difficult to diagnose because of heterogenous presentation.
Adult-Onset Still's ... Disease (AOSD) ... salmon-colored maculopapular ... rash, arthritis ... #Disease #AOSD
Adult Onset Still's Disease Systemic inflammation with urticarial rash. Rash: • Nonpruritic, evanescent (correlates with time of
Adult Onset Still's ... nonpruritic macular or maculopapular ... extremities during febrile ... #Stills #disease ... #AOSD #diagnosis
Maculopapular Rashes - THE ALGORITHMIC APPROACH The term maculopapule is a portmanteau, a combination of macule and
appear toxic and febrile ... differential diagnosis ... assessed for Lyme disease ... pathognomonic for SJS or EM ... require emergent evaluation
Adult Onset Still's Disease - Yamaguchi Criteria Major criteria: - Fever >= 39C lasting >= 1 weeks
Adult Onset Still's ... criteria: - Fever ... - Typical skin rash ... : maculopapular, ... #Criteria #Diagnosis
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
sJIA) • Adult-onset ... Still disease ... Petechial or purpuric rash ... erythematosus [SLE], AOSD ... Activation #Syndrome #Diagnosis
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
< 30 years • Aorta ... Arteritis): • Aorta ... , mucositis • Rash ... Nervous System: • Onset ... vesicles, pustules, maculopapular
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
Mediated: • Febrile ... /sx urticaria, maculopapular ... rash, pruritis, ... resembles ARDS, onset ... #Transfusion #diagnosis
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
Mediated: - Febrile ... /sx urticaria, maculopapular ... rash, pruritis, ... resembles ARDS, onset ... #Transfusions #diagnosis
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