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diagnosis lupus druginduced arteritis cell comparison dil disease erythematosus giantcell hemophagocytic hlh igg4 lymphohistiocytosis oncology phenotypes plasmacytoma polychondritis relapsing related
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Summary • Epidemiology ... • Immunologic Workup ... life-threatening • Treatment ... of SLE • Evolution ... #Summary #rheumatology
IgG4-Related Disease Clinical history: Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor 4 phenotypes: •
Retroperitoneum and aorta ... diagnosis (new biopsy ... Disease #diagnosis #management ... #phenotypes #workup ... #treatment #rheumatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
• Immunologic Workup ... • Immunologic Workup ... of SLE • Evolution ... comparison #table #rheumatology ... #diagnosis #management
Giant cell arteritis (GCA) Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
those coming off aorta ... of the steroid treatment ... Treatment of GCA ... them, but urgent rheumatology ... Symptoms #Diagnosis #Management
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Autoimmune diseases: SLE ... inhibitors under evaluation ... Lymphohistiocytosis #diagnosis #management ... #treatment #summary ... #rheumatology
Drug Induced Lupus (DIL) • Epidemiology: -10% of all lupus cases, drug-dependent, 4:1 to 1:1 F:M
is rare in DIL, SCLE-DIL ... • Immunologic Workup ... DrugInduced #Lupus #DIL #rheumatology ... #diagnosis #treatment ... #management
Relapsing Polychondritis What is it? Recurrent inflammation of the cartilage in the body (Autoimmune disorder) Who? • Most frequently: 40
Large vessels (aorta ... cases such as: • SLE ... CRP, ANA + • Biopsy ... Polychondritis #rheumatology ... #diagnosis #management
Solitary Cell Plasmacytoma What? • Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) • In 3%
Diagnostic Evaluation ... + diff • CMP, Ca ... Bone marrow Treatment ... Oncology #Diagnosis #Workup ... #Hematology
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