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hematology algorithm anemia differential management disease workup causes gastroenterology hemolytic agglutinin aplastic b12 blood carcinoma cbc cobalamin cold disorders gastrointestinal
Gastrointestinal Evaluation of Iron Deficiency Anemia In patients with anemia, diagnose iron deficiency if: • Ferritin <
Gastrointestinal Evaluation ... with anemia, diagnose ... tests Test for celiac ... Non-invasive testing ... #Evaluation #workup
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
- Differential Diagnosis ... bartonella (oroya fever ... #Differential #Diagnosis ... Algorithm #workup #hematology ... #testing
Bandemia Overview Normal: < 1% Clinically significant: > 10% Band neutrophils are slightly less mature than segmented neutrophils and
Differential Diagnosis ... especially in the setting ... tachycardia or fever ... count on initial evaluation ... #CBC #hematology
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
- Differential Diagnosis ... Artifact (redo CBC ... disorders • Celiac ... malignancy • Iron deficiency ... anemia #Thrombocytosis
Celiac Disease Testing Algorithm INDICATIONS FOR TESTING: Nonspecific symptoms (iron-deficiency anemia, failure to thrive, fever, skin
Celiac Disease Testing ... symptoms (iron-deficiency ... anemia, failure ... to thrive, fever ... #Algorithm #diagnosis
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Presentation: • Fever ... , GATA2 deficiency ... , CTLA4 deficiency ... • ↓ WBC • ↓ ... #diagnosis #management
Evaluation of suspected incomplete Kawasaki Disease 1. AHA consensus recommendations 2. Infants ≤6 months old on day ≥7
Evaluation of suspected ... old on day ≥7 of fever ... should undergo lab testing ... ≥450,000/mm3, WBC ... #Diagnosis #Peds
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
- Differential Diagnosis ... smear, HIV/HCV testing ... changes), high MCV anemia ... - Bone marrow evaluation ... #Differential #Diagnosis
Vitamin B12 (Cobalamin) Deficiency Etiology: • Vit B12 - aka cobalamin. Present in foods derived from animal
B12 (Cobalamin) Deficiency ... related to IBD, celiac ... total body stores Evaluation ... • Labs: - CBC ... #diagnosis #management
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Positive Coombs testing ... Blood smear - RBC ... post infectious setting ... Symptoms: High fevers ... #hematology #diagnosis
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