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diagnosis differential hematology algorithm cobalamin macrocytosis vitaminb12 aafp elevatedmcv falls folate folicacid geriatrics homocysteine management mcv mds mma morphologic myelodysplasia
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... • Drugs Oval Macrocytes ... • Dietary Deficiency ... - Low Serum B12 ... #Macrocytic
Diagnostic Framework for Anemia (Morphological Approach - MCV) Low MCV - <80fL - "Microcytic" • Iron deficiency
Approach - MCV) Low ... chronic kidney disease ... MCV - >96fL - "Macrocytic ... Megaloblastic: Vitamin B12 ... differential #diagnosis #causes
Algorithm for the evaluation of macrocytic anemia. (RBC = red blood cell; MMA = methylmalonic acid.) Physicians
Algorithm for the evaluation ... of macrocytic anemia ... the most likely cause ... recovery also causes ... deficiency.
Causes of Low Vitamin B12 Levels Low vitamin B12 intake - Vegetarianism, chronic alcoholism and older people Autoimmune
Causes of Low Vitamin ... B12 Levels Low ... vitamin B12 intake ... Autoimmune - Pernicious anaemia ... , coeliac disease
Vitamin B12 (Cobalamin) Deficiency Etiology: • Vit B12 - aka cobalamin. Present in foods derived from animal
• Common Causes ... : • Worsening macrocytic ... related to IBD, celiac ... disease, other ... total body stores Evaluation
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... common cytopenia: Macrocytic ... Myeloproliferative Disease ... Nutritional: vitamin B12 ... Workup: • Complete
Evaluation of Recurrent Falls Core Concept: Maintaining an upright posture requires the integrated function of multiple systems. Disruption in
Evaluation of Recurrent ... embolism - Severe anemia ... e.g., diabetic, B12 ... deficiency) ... muscle wasting, slow
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