11 results
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
and Platelet Disorders ... Diagnosis and Workup ... smear, HIV/HCV testing ... - Bone marrow evaluation ... #Workup #hematology
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm
Thrombocytopenia - Quantitative Defect
 • Decreased Production
 •
Causes of Bleeding ... Sequestration Disordered ... Platelet Function ... Connective Tissue Disorders ... #Hematology
Eosinophil Disorders Testing Algorithm
INDICATIONS FOR TESTING:
 • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
Eosinophil Disorders ... during medical evaluation ... or workup for specific ... 1,500 cells/µL Workup ... Differential #diagnosis #hematology
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework

== Quantitative or Qualitative defect in
Qualitative defect in platelets ... characteristic of a platelet ... discern these causes ... fibrinogen levels, and testing ... Differential #Diagnosis #Hematology
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
' nucleotidase deficiency ... with or without platelet ... Consider RBC membrane disorder ... Diagnosis #Algorithm #workup ... #hematology #testing
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
are a group of disorders ... formed or don’t work ... Disorders • Nutritional ... Workup: • Complete ... Syndromes #diagnosis #hematology
Causes of Petechial Rash - Differential Diagnosis Algorithm

Pinpoint areas (less than 2 mm) of hemorrhage, which
Causes of Petechial ... Thrombocytopenia - Abnormal platelet ... Clotting factor deficiency ... Vasculitis - Collagen disorders ... Work Up: •
Helpful Clinical Features in Evaluating Bleeding Disorders
Age of onset
 • Neonate - in 20% of haemophilias,
Clinical Features in Evaluating ... Bleeding Disorders ... characteristic of platelet ... or factor XIII deficiency ... #Bleeding #Disorders
Blood Product Transfusions One Pager Summary
Type and screen - determines blood type and detects in recipient
Crossmatch - involves testing ... recipients w/ IgA deficiency ... Causes purpura & ... false negatives on testing ... diagnosis #management #hematology
Blood Transfusion Reactions

Immune Mediated:
 • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
recipients w/ IgA deficiency ... Causes purpura & ... cause of transfusion ... false negatives on testing ... diagnosis #management #hematology