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diagnosis rheumatology management differential druginduced vasculitis approach bcnie bloodculture classification comparison cryoglobulinemia cryoglobulins dil disease endocarditis erythematosus gravis infectiousdiseases infective
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
to 1:1 F:M • Clinical ... Constitutional symptoms, Arthritis ... • Immunologic Workup ... 40, F:M 9:1 • Clinical ... • Immunologic Workup
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... 40, F:M 9:1 • Clinical ... • Immunologic Workup ... Positive in 60-80% of cases ... • Evolution:
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Rheumatology Workup ... joint • Systemic lupus ... • Hepatitis B serology ... ANA and RF (if clinical ... #workup #diagnosis
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... Cryoglobulins Cause ... Syndrome: • Clinical ... (e.g. systemic lupus ... ), rheumatoid arthritis
Approach to Joint Pain - Diagnostic Framework 1) Chronicity 2) Inflammatory vs Non-Inflammatory 3) Number of Joints Involved 1) Chronicity:
bacterial), acute rheumatic ... spondyloarthropathies, lupus ... Like in this case ... Chronic = RA, SLE ... rheumatology #approach #workup
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Diagnosis: • Systemic rheumatic ... diseases, such as SLE ... PMR (Polymyalgia Rheumatica ... rhinitis/sinusitis, saddle ... tract, and often causes
Blood Culture-Negative Infective Endocarditis (BCNIE) Definition: No etiology found after 3 separate blood cultures remain negative for
BCNIE relies on evaluation ... antimicrobials, clinical ... but important causes ... See charts - ... antinuclear antibodies, rheumatoid
Myasthenia Gravis Overview Myasthenia Gravis is an autoimmune disorder of the postsynaptic neuromuscular junction. Ab to
Sjogren syndrome, rheumatoid ... arthritis, SLE ... Clinical Picture ... Clinical DX: - ... diagnosis #management #neurology
Drug Induced Lupus (DIL) • Epidemiology: -10% of all lupus cases, drug-dependent, 4:1 to 1:1 F:M
to 1:1 F:M • Clinical ... Constitutional symptoms, Arthritis ... is rare in DIL, SCLE-DIL ... • Immunologic Workup ... Discontinuation of causal
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