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differential disease hemophagocytic hlh lymphohistiocytosis syndrome lupus lymphoma sle symptoms treatment activation adult algorithm antinxp2 antinxp2dm aosd arteritis behcet calcium
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison Hodgkin's Lymphoma: • Epidemiology: young adults 20-30, older 50-70 •
Lymphoma - Comparison ... • Other hematologic ... Malignancies (eg CML ... #oncology #diagnosis ... #differential #hematology
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
- Differential Diagnosis ... Reactive: - Systemic ... Inflammatory • Systemic ... Algorithm #Causes #Hematology ... #Oncology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
classical HL (MCHL ... lymph node biopsy (diagnostic ... #lymphoma #diagnosis ... classification #hematology ... #oncology #management
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
rendering the immune system ... identical to the non-Hodgkin ... Physical Exam/Signs ... #workup #oncology ... #hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Seen in: • Systemic ... 5000 to 10,000 ng/mL ... Activation #Syndrome #Diagnosis ... #Management #Hematology ... #Rheumatology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
(HCV) • CLL & MBL ... neuropathy) • Systemic ... Paraproteinemias #Hematology ... #Differential #Diagnosis ... #Oncology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Ferritin >1000 ng/ml ... sIL-2R >2400 Ul/ml ... Hemopathies+++: Hodgkin ... #management #treatment ... #summary #rheumatology
Giant cell arteritis (GCA) Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
Diagnosis = clinical ... signs/sx of inflammation ... them, but urgent rheumatology ... GCA #Temporal #Signs ... #Management
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
Behçet's Syndrome Systemic ... artery aneurysms Diagnosis ... ) Differential Diagnosis ... #management #signs ... #symptoms #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
: HLH signs and ... Diagnosis via genetic ... Ferritin >500 ng/mL ... #management #treatment ... #hematology
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