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management differential hematology neurology syndrome als amyotrophic caudaequina excess gh glftap growthhormone hemeonc hemophagocytic hlh hyperthyroidism lateral leukostasis lymphohistiocytosis lysis
Cauda Equina Syndrome Causes: • Large lumbar degenerative disc herniation (central) • Severe lumbar spondylosis • Neoplasm
Equina Syndrome Causes ... Incontinence • Saddle Anesthesia ... Syndrome #MSK #pathophysiology ... #diagnosis #symptoms ... #signs
Growth Hormone Excess - Pathogenesis and clinical findings • Acromegaly and gigantism share the same pathophysiology
• Other rare causes ... Overproduction #diagnosis ... #signs #symptoms ... #endocrinology ... #pathophysiology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... high WBC count cause ... WBC >100k, + lab signs ... Lysis Syndrome: • Pathophysiology ... Syndrome #TLS #diagnosis
Pituitary Mass Effects - Pathogenesis and Clinical Findings • Pituitary turnors are almost always a benign
adenomas that require treatment ... For pituitary masses ... Signs / Symptoms ... #SideEffects #endocrinology ... mnemonic #GLFTAP #pathophysiology
Hyperthyroidism Overview Clinical Manifestation of Hyperthyroidism: • Fatigue • Weight loss • Heat intolerance • Depression, nervousness
↑ AST/ALT • Treatment ... tenderness Treatment ... hyperthyroidism #causes ... #endocrinology ... #signs #symptoms
Pheochromocytoma - Diagnosis and Management Summary 10 percent rule = 10% of pheochromocytomas are extra-adrenal, multiple, bilateral,
malignant, pediatric cases ... life • M=F Symptoms ... and Signs: 50% ... and signs: • ... , induction of anesthesia
Amyotrophic Lateral Sclerosis (ALS) Summary ALS: combination of the clinical examination finding of amyotrophy with the pathologic
lateral sclerosis Pathophysiology ... - Causes progressive ... fasciculations Common Symptoms ... Escorial criteria uses ... column Treatment
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
monophasic Pathophysiology ... bouts of HTN Diagnostic ... • Bilateral signs ... and/or symptoms ... Transverse Myelitis Treatment
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
hyperinflammatory syndrome caused ... Presentation • Common Signs ... and Symptoms: ... Pathophysiology ... Treatment Approach
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