12 results
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm
Volume Depleted 2° hyperaldosteronism
 • Low Urine Cl-: Vomiting, NGT
Primary Metabolic ... - Differential Diagnosis ... Urine Cl-: Vomiting ... , Gitelman Syndrome ... #Algorithm #nephrology
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm
Volume Depleted - 2° hyperaldosteronism
 • Low Urine Cl-: Vomiting,
Primary Metabolic ... - Differential Diagnosis ... Urine Cl-: Vomiting ... , Gitelman Syndrome ... #Algorithm #Nephrology
Algorithm for patients with hypokalemia on the basis of the potassium-to-creatinine ratio in the urine
Urine K+
Urine K+ <13 mEq ... Urine Cl - Non-reabsorbable ... , Gitelman syndrome ... differential #algorithm #diagnosis ... #nephrology
Metabolic Alkalosis - Urinary Chloride Algorithm
Cl- responsive metabolic alkalosis
 • Kidney loss of Cl-
alkalosis • Normal/low ... , Gitelman syndrome ... sodium is typically ... #Algorithm #nephrology ... #differential #diagnosis
Inherited Defects in Kidney Tubule Epithelial Cells

Renal glucosuria - Na+-dependent glucose cotransporter
Cystinuria - Amino acid transporter
Bartter
- Na-K-2Cl cotransporter ... , K channel, Cl ... ascending limb Gitelman ... Defects #Kidney #Nephrology ... #Diagnosis #Differential
Hypokalemia Evaluation Algorithm

Before evaluating hypokalemia, life threatening complications such as arrhythmias and paralysis should be looked
A urine K/Cr ratio ... , Gitelman syndrome ... #Hypokalemia #diagnosis ... differential #potassium #nephrology ... #low
Gitelman Syndrome Pathophysiology
Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
Gitelman Syndrome ... thiazide-sensitive sodium-chloride ... nephron → - ↑ K+ ... → Hypokalemia Metabolic ... #nephrology #diagnosis
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm
Volume Depleted - 2° hyperaldosteronism
 • Low Urine Cl-: Vomiting,
Primary Metabolic ... - Differential Diagnosis ... Urine Cl-: Vomiting ... , Gitelman Syndrome ... #Algorithm #Nephrology
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
Gitelman Syndrome ... alkalosis • Normal or low ... Hypocalciuria (spot urine ... #Syndrome #diagnosis ... #nephrology #management
Gitelman Syndrome - Diagnosis and Workup
Blood Work:
 - Hypokalemia
 - Hypomagnesemia
 - Metabolic Alkalosis
 - Elevated
Gitelman Syndrome ... Hypomagnesemia - Metabolic ... Elevated Renin Urine ... Inappropriate renal K+ ... #Syndrome #Diagnosis