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diagnosis differential management nephrology neurology pediatrics dermatology peds clinical hepatology hematology endocrinology cardiology obgyn ophthalmology acute ddxof workup pathophysiology primary
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Differential Diagnosis Algorithm ... — Normal Bile Ducts ... Stone • Biliary ... Differential #Diagnosis #Algorithm ... #Causes
Jaundice - Differential Diagnosis Algorithm Pre-Hepatic - Unconjugated Hyperbilirubinemia Increased Production • Hemolysis • Ineffective Erythropoiesis • Hematoma Decreased
Differential Diagnosis Algorithm ... - Usually has Duct ... on Ultrasound Biliary ... Duct Compression ... #Causes #Hepatology
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm ALP: - Enzymes that catalyze hydrolysis of organic phosphate
Differential Diagnosis Algorithm ... Intestine - Other causes ... Drugs - Primary biliary ... PSC - Other biliary ... diseases/Bile duct
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Differential Diagnosis Algorithm ... Vascular Causes ... Extrahepatic - Biliary ... Surface of bile duct ... differential #diagnosis #algorithm
Coarctation of the Aorta Preductal Coarctation: Narrowing is proximal to ductus arteriosus Life-threatening if severe; seen in
is proximal to ductus ... at insertion of ductus ... Appears when ductus ... closes Postductal ... distal to the ductus
Classification of Jaundice Unconjugated hyperbilirubinemia (predominantly indirect bilirubin) • Increased bilirubin production (eg, hemolytic anemias, hemolytic reactions,
cholestasis, and some cases ... miscellaneous causes ... duct, sclerosing ... pressure on bile duct ... #differential #causes
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
Primary Biliary ... intralobular bile ducts ... causes cholestasis ... No extrahepatic biliary ... malignancy #Primary #Biliary
Diseases of the Biliary Tract Asymptomatic gallstones - Asymptomatic Symptomatic gallstones - Biliary pain Cholesterolosis of gallbladder - Usually
Diseases of the Biliary ... Adenomyomatosis - May cause ... biliary pain Porcelain ... quadrant pain, nausea ... quadrant pain, nausea
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
Differential Diagnosis Algorithm ... - Normal Bile Ducts ... - Dilated Bile Ducts ... - CBD stone, Biliary ... Transaminitis #Algorithm
Causes of Severe Acute Liver Injury - Ichemic hepatitis - Acute biliary obstruction - Drug-Induced liver
Causes of Severe ... hepatitis - Acute biliary ... Hemochromatosis - Primary biliary ... Severe #Acute #Causes
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