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diagnosis differential management acidosis algorithm nephrology pharmacology pathophysiology classification diabetes metabolic treatment aniongap ckd criticalcare toxicology typeb antibiotics clinical infectiousdiseases
Metformin Pharmacology Summary Mechanisms of Action: • Suppresses gluconeogenesis by the liver • Increases insulin-mediated glucose utilization
Metformin Pharmacology ... agent • Does not cause ... not initiate if eGFR ... not continue if eGFR ... about causing lactic
Metformin Current Renal Dose Adjustments due to Risk of Lactic Acidosis > 60 No adjustment 45-60
Metformin Current ... due to Risk of Lactic ... 45-60 Monitor eGFR ... already taking metformin ... /ambcarerx #Metformin
Metformin in Diabetic Kidney Disease Immediate release: • Initial 500 mg or 850 mg once daily •
Metformin in Diabetic ... maximum dose eGFR ... recommended dose eGFR ... < 30: Stop metformin ... annually if on metformin
Lactic Acidosis Classification - Type A vs Type B Type A Lactic Acidosis: Sepsis, Ischemic bowel, Hemorrhagic
Lactic Acidosis ... Type B Type A Lactic ... Cardiogenic shock Type B Lactic ... Renal failure, Metformin ... transcriptases, Linezolid #Lactic
Metformin Associated Lactic Acidosis (MALA) Pathophysiology of MALA - Metformin interferes with the activity of the
Metformin Associated ... Lactic Acidosis ... Pathophysiology of MALA - Metformin ... concentrations > 5 μg/mL, metformin ... Kat_Watson #MALA #Metformin
Anion Gap Metabolic Acidosis • Diabetic Ketoacidosis ± Hyperglycemia ± Hyperosmolar • Alcoholic Ketoacidosis ± Hyperglycemia
glycol • Type B lactic ... Drugs ( Albuterol, Metformin
Lactic Acidosis - Classification and Differential Diagnosis Type A Lactic Acidosis: Inadequate Oxygen Delivery • Anaerobic muscular
Lactic Acidosis ... Diagnosis Type A Lactic ... Anemia Type B Lactic ... Lactate-based dialysate, Metformin ... 0885066620982585 #Lactic
Management of Diabetes Mellitus in Patients With CKD 1. Monitor for changes in BP, serum creatinine, &
FDA recommends, metformin ... T2D, CKD, & an eGFR ... per 1.73 m2 with metformin ... CKD #ADA #KDIGO #eGFR ... #Insulin #metformin
Kussmaul Breathing in Lactic Acidosis Acute non-cardiopulmonary dyspnoea. 70 ys, DM, vomiting and URQ abdominal pain since
Kussmaul Breathing in Lactic ... BGA: severe lactic ... regularly taken metformin
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 Metformin: Biguanide Metformin is the first-line medication for treatment of type 2 diabetes. It is very effective
Metformin: Biguanide ... Metformin is the ... function since lactic ... /ambcarerx #Metformin
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