38 results
Metformin Pharmacology Summary
Mechanisms of Action:
 • Suppresses gluconeogenesis by the liver
 • Increases insulin-mediated glucose utilization
Metformin Pharmacology ... not initiate if eGFR ... not continue if eGFR ... about causing lactic ... EricsMedicalLectures/ #Metformin
Metformin 
Current Renal Dose Adjustments due to Risk of Lactic Acidosis 
> 60 No adjustment 
45-60
Metformin Current ... due to Risk of Lactic ... 45-60 Monitor eGFR ... already taking metformin ... /ambcarerx #Metformin
Diabetes Combination Tablets - Estimated A1c Lowering 
Metformin + DPP4 
• Janumet (metformin + sitagliptin) 
•
A1c Lowering Metformin ... DPP4 • Janumet (metformin ... • Jentadueto (metformin ... saxagliptin) Metformin ... Tablets #Oral #DM2
Metformin in Diabetic Kidney Disease
Immediate release:
 • Initial 500 mg or 850 mg once daily
 •
Metformin in Diabetic ... maximum dose eGFR ... recommended dose eGFR ... < 30: Stop metformin ... annually if on metformin
Lactic Acidosis Classification - Type A vs Type B
Type A Lactic Acidosis: Sepsis, Ischemic bowel, Hemorrhagic
Lactic Acidosis ... Type B Type A Lactic ... Cardiogenic shock Type B Lactic ... Renal failure, Metformin ... transcriptases, Linezolid #Lactic
Kussmaul Breathing in Lactic Acidosis
Acute non-cardiopulmonary dyspnoea. 70 ys, DM, vomiting and URQ abdominal pain since
Kussmaul Breathing in Lactic ... dyspnoea. 70 ys, DM ... BGA: severe lactic ... regularly taken metformin
Diabetes Type 2 Medication Management and Titration Algorithm
- First line therapy is metformin and comprehensive lifestyle
line therapy is metformin ... CKD #Diabetes #DM2
Management of Diabetes Mellitus in Patients With CKD

1. Monitor for changes in BP, serum creatinine, &
FDA recommends, metformin ... T2D, CKD, & an eGFR ... ml/min per 1.73 m2 ... with metformin. ... CKD #ADA #KDIGO #eGFR
Metformin - First Line Treatment for Diabetes Type 2
• Start with initial dose of 500 mg
Metformin - First ... medication #Metformin ... Pharmacology #Diabetes #DM2
Metformin Associated Lactic Acidosis (MALA) 

Pathophysiology of MALA
 - Metformin interferes with the activity of the
Metformin Associated ... Lactic Acidosis ... Pathophysiology of MALA - Metformin ... concentrations > 5 μg/mL, metformin ... Kat_Watson #MALA #Metformin