2737 results
Patient factors influencing the selection Of glucose-lowering drugs Other than SGLT2i and metformin in T2D and
cardiovascular disease ... chronic kidney disease ... —4 inhibitor, eGFR ... CKD #management #treatment
Chronic Kidney Disease (CKD):

Individualize BP-lowering therapy and treatment targets in people with frailty, high risk of
Chronic Kidney Disease ... BP-lowering therapy and treatment ... Treatments that ... Initial dips in eGFR ... #CKD #eGFR #Kidney
The GFR Clock for Staging CKD

Staging CKD is most frequently done by calculating the estimated glomerular
The GFR Clock for ... function rate (eGFR ... calculating the eGFR ... to remember the eGFR ... #Nephro #CKD #EGFR
Interpreting Kidney Biomarkers

↑ Creatinine: 
 • AKI, CKD
 • Medications that lead to nephroprotective ↓ in
nephroprotective ↓ in GFR ... hyperthyroidism ↓ eGFR
Definitions of AKI, CKD, AKD
Acute Kidney Injury (AKI):
 • Increase in SCr by 2 50% within
Chronic Kidney Disease ... (CKD): • GFR ... Acute Kidney Diseases ... months No Kidney Disease ... (NKD): • GFR
Renal Failure Prognosis - The eGFR and proteinuria offers a general prognosis as demonstrated in the
Prognosis - The eGFR ... #CKD #EGFR #Proteinuria
To improve the usefulness of the serum creatinine concentration as a marker of kidney function, prediction
accurately predict GFR ... overestimation of GFR ... Diet in Renal Disease ... used to estimate GFR ... CockcroftGault #EGFR
Hepatorenal Syndrome (HRS) - Diagnostic Criteria
HRS-AKI (Acute: previously known as HRS Type 1)
 • ↑ Creatinine
months - eGFR ... cause of kidney disease ... HRS-CKD - eGFR ... cause of kidney disease
Metformin in Diabetic Kidney Disease
Immediate release:
 • Initial 500 mg or 850 mg once daily
 •
Diabetic Kidney Disease ... maximum dose eGFR ... recommended dose eGFR
Metformin Pharmacology Summary
Mechanisms of Action:
 • Suppresses gluconeogenesis by the liver
 • Increases insulin-mediated glucose utilization
Chronic kidney disease ... not initiate if eGFR ... not continue if eGFR ... • Severe liver disease